Trazodone succinate — new opportunities for pharmacological correction of situational behavioral abnormalities in dogs and cats

Abstract

Currently, the interest of veterinarians and owners in the pharmacological correction of situational behavioral disorders in companion animals has increased significantly. To quickly correct deviant behavior in dogs and cats, veterinarians use some of the psychotropic drugs used in humane medicine, in particular, trazodone, an antidepressant antagonist / serotonin reuptake inhibitor.
 
 Based on the analysis of literature sources, data on the history of creation and pharmacological properties, assessment of the safety and efficacy of drugs based on trazodone hydrochloride in behavioral medicine of small pets are provided.
 The data on the prerequisites for the development, pharmaco-toxicological and clinical evaluation of a new drug for the modification of abnormal behavior in dogs and cats, Express Uspokoin® tablets based on trazodone succinate, which, with a high efficiency of the target action, made it possible to achieve the absence of side effects and significantly increase the tolerance of the dosage form by animals, are analyzed. compared with preparations based on trazodone hydrochloride.

Tolerability of the new drug Kurs Uspokoin tablets for dogs in chronic study

“…При биотрансформации сукцинат тразодона служит источником янтарной кислоты, которая, воздействуя на нервную систему, модулирует активность ферментов клеточных мембран (кальцийнезависимой фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы) и рецепторных комплексов (бензодиазепинового, ГАМК, ацетилхолинового), улучшает синаптическую передачу, способствует сохранению структурно-функциональной организации биомембран, повышению концентрации в головном мозге дофамина. Янтарная кислота обладает антиоксидантными свойствами, восполняет энергетический дефицит клеток и тканей за счет компенсации недостатка выработки янтарной кислоты в митохондриях [10].…”