The second for the significance livestock sector is pig breeding, which accounts for one-third of the country’s meat production. Long-term world practice of pig farming confirms the high maturity of this species of animals, excellent taste, nutritious meat and most importantly the ability to quickly increase food production, and thereby ensure the optimal balance of the diet of the population. One of the constraining factors for the development of this industry is the development of iron deficiency alimentary anemia in pigs during the first 7 days of animal life, which affects the growth, development and increase of live weight in animals. Without preventive measures to supplement the iron with animals, up to 100% of piglets become sick with anemia, which can lead to the death of a significant part of the young population. This article presents the results of the toxicological approbation of a new iron-containing preparation for farm animals. The question of finding a less toxic iron preparation with a higher prolonging effect is relevant.
This paper describes the results of parasitological monitoring of pond farms in the Krasnodar region. It was found that in the warm-water aquaculture of various systems, 25 species of fish parasites were invaded, and the fauna of parasites was determined. The obtained results are the basis for the analysis of the system of medical and preventive measures and actualize the development of new means and methods of treatment and prevention of diseases. It is established that the complex anthelmintic drug, according to the generally accepted classification of chemical compounds in accordance with the degree of danger, can be attributed to moderately hazardous compounds, and by cumulative properties - to the group of substances with weakly expressed cumulation. With repeated administration of the new drug to fish, there were no significant changes in the clinical status, some hematological and biochemical parameters, which is one of the necessary conditions for the possibility of using anthelmintic in clinical studies. As a result of a single therapeutic feeding with the use of a combined anthelmintic at a dose of 50 mg/kg, the 100% extensive and intensive efficiency of the deworming of carps invaded by Philometroides lusiana and Bothriocephalus acheilognathi was obtained.
Targeting is a phenomenon in which the distribution of a drug in the body occurs in such a way that the main part of it interacts with the target tissue at the cellular or subcellular level to achieve the desired pharmacological effect on the selected site without undesirable interactions in other organs. This can be achieved using a drug delivery system such as niosomes, which are non-ionic vesicles of surfactants obtained by hydrating synthetic non-ionic surfactants with the inclusion of cholesterol. They are vestibular systems similar to liposomes that can be used as carriers of amphiphilic or lipophilic drugs. Niosomes are a promising drug delivery tool, and it has been widely evaluated as a possibility of controlled release and targeted delivery of the active substance for the treatment of cancer, autoimmune diseases, viral and other infectious diseases. It can be assumed that encapsulation of the drug in the vesicular system prolongs its presence in the systemic circulation and increases the possibility of penetration into the target tissue, possibly reducing toxicity if selective absorption can be achieved.
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