The second for the significance livestock sector is pig breeding, which accounts for one-third of the country’s meat production. Long-term world practice of pig farming confirms the high maturity of this species of animals, excellent taste, nutritious meat and most importantly the ability to quickly increase food production, and thereby ensure the optimal balance of the diet of the population. One of the constraining factors for the development of this industry is the development of iron deficiency alimentary anemia in pigs during the first 7 days of animal life, which affects the growth, development and increase of live weight in animals. Without preventive measures to supplement the iron with animals, up to 100% of piglets become sick with anemia, which can lead to the death of a significant part of the young population. This article presents the results of the toxicological approbation of a new iron-containing preparation for farm animals. The question of finding a less toxic iron preparation with a higher prolonging effect is relevant.
The effectiveness of a new anthelmintic drug for dogs and cats Supramil® tablets was studied. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to dogs and puppies at a dose of 2.5 mg / kg for R-praziquantel and 0.5 mg / kg for milbemycin oxime was 100%. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to cats and kittens at a dose of 2.5 mg / kg for R-praziquantel and 2.0 mg / kg for milbemycin oxime was 100%. Thus, Supramil® tablets are a highly effective treatment for the most common intestinal helminthiases of dogs and cats.
The article presents the results of studying the physicochemical properties of exosome preparations obtained by ultrafiltration, which indicate a high degree of the composition and properties dependence of the obtained product on the material of the filters used. Quantitative determination of proteins and nucleic acids in exosome samples using UPN-50 filters allows us to conclude that the content of the main impurity compounds in the preparation is significantly reduced compared to dispersions obtained using filters with pore sizes of 220 and 450 nm. Analysis of flow cytometry data made it possible to demonstrate that when using the UPN-50 filter, an increase in the contribution to the dispersion of all types of fractions of non-exosomal size was observed, the appearance of which can result from fraction destruction associated with pore size or filter material properties. drying of the dispersion was observed in the studied exosome samples. Fraction sizes ranged from 40 to 450 nm (an average of about 200 nm). Exosomes from the entire variety of membrane vesicles are fractions that have the most suitable characteristics that allow them to be used as a nanoscale drug delivery vehicle while ensuring the necessary quality control of the drug at the sample preparation stage.
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