Efficacy of the new anthelmintic drug Supramil® tablets in intestinal helminthiases of dogs and cats

The effectiveness of a new anthelmintic drug for dogs and cats Supramil® tablets was studied. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to dogs and puppies at a dose of 2.5 mg / kg for R-praziquantel and 0.5 mg / kg for milbemycin oxime was 100%. Therapeutic efficacy of the drug Supramil® tablets after a single application of spontaneously infested intestinal nematodes and / or cestodes to cats and kittens at a dose of 2.5 mg / kg for R-praziquantel and 2.0 mg / kg for milbemycin oxime was 100%. Thus, Supramil® tablets are a highly effective treatment for the most common intestinal helminthiases of dogs and cats.

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Efficacy of the new anthelmintic drug Supramil® tablets in intestinal helminthiases of dogs and cats

Orobec

Sevostyanova

Заиченко

et al. 2022

Russian Veterinary Journal

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Evaluation of a preventive efficacy for a new anthelminthic drug Supramil® tablets regarding heartworm disease in dogs

Shinkarenko¹,

Kamenov²,

Mukaseev

et al. 2022

Russian Veterinary Journal

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There was studied an effectiveness of the new anthelmintic drug Supramil® tablets for prevention of dirofilariasis in dogs. With a monthly treatment of dogs free from larvae of Dirofilaria spp. with the drug Supramil® tablets, used at dose of 0.5 mg / kg on a body weight according to milbemycin oxime, in a region unfavorable for dirofilariasis, the preventive effectiveness of the drug was 100 %. Monthly control of microfilariaemia, carried out before each drug treatment, showed an absence of larvae of Dirofilaria spp. in peripheral blood of 100% of experimental animals, which indicates not only high preventive efficacy of the drug, but also its prolonged microfilaricidal action and a possibility to use it for prevention of dirofilariasis with an interval of 28…35 days. Thus, Supramil® tablets are highly effective to prevent dirofilariasis in disadvantaged regions.

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Study of bioequivalence of veterinary drugs “Pinpramil” and “Milbemax” in dogs

Abramov,

Balyshev,

Golovin

et al. 2024

Agrarnaâ nauka

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The article presents the results of studying the bioequivalence of the reproduced drug “Pinpramil” in comparison with the reference drug “Milbemax”. The experiments were conducted on 12 dogs, which were divided into two equal groups of 6 animals each. Dogs of one of the groups were given a reproduced drug, and animals of the other group were given a reference drug. The studied drugs were injected into the body of dogs once, individually, orally at a dose of the active substance, which corresponded to 0.5 mg of milbemycin oxime and 5 mg of praziquantel per 1 kg of body weight. After administration of the drugs, blood samples were taken from animals 14 times within 96 hours for subsequent production of serum, in which the content of praziquantel (including its active metabolite, trans-4-hydroxypraziquantel) and milbemycin oxime were determined by high-performance liquid chromatography. The obtained concentrations of these substances served as the basis for calculating their pharmacokinetic parameters in the body of dogs. The statistical analysis showed that the two-way confidence intervals for the Cmax, AUC0-t, AUC0-∞ ratios were in the range of 80–125%, and the Cmax/AUC0-t ratios were 75–133%. Thus, the research results have demonstrated that the drugs “Pinpramil” and “Milbemax” are bioequivalent.

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Efficacy of the new anthelmintic drug Supramil® tablets in intestinal helminthiases of dogs and cats

Cited by 3 publications

References 12 publications