Evaluation of a preventive efficacy for a new anthelminthic drug Supramil® tablets regarding heartworm disease in dogs

Abstract

There was studied an effectiveness of the new anthelmintic drug Supramil® tablets for prevention of dirofilariasis in dogs. With a monthly treatment of dogs free from larvae of Dirofilaria spp. with the drug Supramil® tablets, used at dose of 0.5 mg / kg on a body weight according to milbemycin oxime, in a region unfavorable for dirofilariasis, the preventive effectiveness of the drug was 100 %.
 Monthly control of microfilariaemia, carried out before each drug treatment, showed an absence of larvae of Dirofilaria spp. in peripheral blood of 100% of experimental animals, which indicates not only high preventive efficacy of the drug, but also its prolonged microfilaricidal action and a possibility to use it for prevention of dirofilariasis with an interval of 28…35 days.
 Thus, Supramil® tablets are highly effective to prevent dirofilariasis in disadvantaged regions.

Study of bioequivalence of veterinary drugs “Pinpramil” and “Milbemax” in dogs

“…Bioequivalence studies allow for a relatively shortterm assessment of the safety and efficacy of a new drug compared to a reference drug that has undergone a comprehensive set of clinical and preclinical studies. This enables the avoidance of prolonged and costly experiments on animals and facilitates the prompt introduction of a new drug to the veterinary market [9][10][11][12].…”