No abstract

No abstract

The results of experiments in dogs with and without two glucose loads and in the isolated pancreas to compare the pharmacodynamics of two low-dosage arylsulphonylureas, glipizide and glibenclamide, are described and discussed.-The results agree with those obtained by other authors confirming that glibenclamide shows delayed but prolonged activity on both plasma insulin and glucose levels. Moreover glibenclamide counteracts the hyperglycaemia induced by the second glucose load less effieently. Glipizide acts faster on insulin and glucose levels, which return quickly to normal. When a second glucose load was given it was still more active in reducing plasma glucose levels. The dynamics of insulin secretion following glipizide more closely resembles tolbutamide than glibenelamide.

No abstract

Die Reaktion der Säurechloride, Ester oder Azide (I) mit p‐(β‐Aminoäthyl)‐ benzolsulfonamid (II) führt zu den Acylaminosulfonamiden (III), die mit Cyclohexylisocyanat (IV) zu den Sulfonylharnstoffen (V) weiter umgesetzt werden.

The influence of a very-low-calorie diet (VLCD) on lipid pattern is controversial. To evaluate the long-term effect of semistarvation on lipid patterns, a group of severely obese patients [aged 37 +/- 12 y, body mass index (BMI) 40.0 +/- 0.9] underwent a VLCD for 8 wk. Total cholesterol (TC), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C), triglycerides (TGs), apolipoproteins A1 (apo A1) and B (apo B) were analyzed every week. TC (6.07 +/- 0.23 vs 5.53 +/- 0.25 mmol/L, P less than 0.0008), HDL-C (mmol/L 1.26 +/- 0.06 vs 1.04 +/- 0.05 mmol/L, P less than 0.0001), TGs (1.46 +/- 0.19 vs 1.06 +/- 0.10 mmol/L, P less than 0.0008), and apo A1 (1.57 +/- 0.06 vs 1.32 +/- 0.06 g/L, P less than 0.0002) decreased, whereas LDL-C and apo B showed a biphasic behavior: they significantly fell during the first 3 wk, but during the last weeks returned to their initial values.

No abstract

No abstract