Prolonged very low calorie diet in obese subjects reduces factor VII and PAI but not fibrinogen levels

Palareti, Gualtiero; Legnani, Cristina; Poggi, M; Parenti, M; Babini, A. C.; Biagi, R; Baraldi, L.; Luchi, A.; Capelli, M.; Coccheri, S.

doi:10.1016/0268-9499(94)90027-2

Cited by 12 publications

(18 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is remarkable that our subjects also experienced a 6% decline in plasma ®brinogen. Mehrabian et al found a similar borderline signi®cant trend, but several others saw no immediate effect of weight loss on ®brinogen (Mehrabian et al, 1990;Palareti et al, 1994;Svendsen et al, 1996). We believe that we can exclude that our ®nding was due to seasonal variation.…”

Section: Discussionsupporting

confidence: 57%

“…Earlier trials reached con¯icting conclusions on this issue and it needs to be investigated in more detail (Leenen et al, 1993;Andersen et al, 1995). Obese individuals experience a 20±30% decline in FVIIc and a 40±60% decline in PAI concentrations when they are on very low calorie diets (Huisveld et al, 1990;Slabber et al, 1992;Palareti et al, 1994). More moderate energy restriction is also associated with marked reductions in FVIIc and PAI-1 (Mehrabian et al, 1990;Folsom et al, 1993;Calles-Escandon et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Most reports concluded that a weight loss of 5 ±15 kg is associated with a 10 ± 20% lowering of total cholesterol and a 20 ±30% lowering of triglycerides (Mehrabian et al, 1990;Folsom et al, 1993;Leenen et al, 1993;Palareti et al, 1994;Andersen et al, 1995;Calles-Escandon et al, 1996). Observations on the immediate effect of weight loss on HDLcholesterol are more inconsistent (Leenen et al, 1993;Mehrabian et al, 1990;Palareti et al, 1994). However, two studies indicated that HDL-cholesterol may increase above pre-slimming levels during weight maintenance (Phinney et al, 1991;Wing et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained by unfavourable plasma lipid pro®les, blood hypercoagulability and impaired endogenous ®brinolysis (Mead et al, 1979;Terry et al, 1989;Folsom et al, 1991;Iso et al, 1993;Sundell et al, 1993). Several earlier trials demonstrated that these abnormalities are corrected with weight reduction as assessed from measurements made during or shortly after slimming (Leenen et al, 1993;Andersen et al, 1995;Huisveld et al, 1990;Mehrabian et al, 1990;Slabber et al, 1992;Peternel et al, 1994;Palareti et al, 1994;Velthuiste Wierik et al, 1995;Calles-Escandon et al, 1996). These studies cannot tell whether the bene®cial biochemical effects are primarily explained by the negative energy balance during slimming, or by the reduced body weight.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects

Marckmann¹,

Toubro²,

Astrup³

1998

Eur J Clin Nutr

View full text Add to dashboard Cite

Objective: To study whether major weight loss causes sustained improvement in blood lipids and haemostatic pro®le in obese subjects, and to compare the in¯uence of two different slimming and maintenance regimens. Design: Two-stranded randomized intervention study. Setting: University Department. Subjects: Thirty-six out of 43 obese patients recruited from out-patient waiting list completed the study. Interventions: Weight loss was achieved by very low energy formula diet (2 MJad for 8 weeks, n 18), or lowenergy conventional diet (5 MJad for 17 weeks, n 18), both combined with anorectic compound. Participants were re-randomized to consume low fat diet ad libitum (n 16), or energy-restricted diet (n 20) for weight maintenance during 24 weeks. Main outcome measures: Plasma lipids, ®brinogen, factor VII coagulant activity (FVIIc), and plasminogen activator inhibitor type 1 (PAI-1) antigen. Results: Weight loss averaged 13.6 kg (95% CI: 12.3 ± 14.9 kg). After 24 weeks' weight maintenance, plasma total cholesterol was 9% lower, high density lipoprotein cholesterol 5% higher, triglycerides 30% lower, FVIIc 12% lower, ®brinogen 6% lower, and PAI-1 antigen 34% lower than at baseline (all changes highly signi®cant). There were no signi®cant differences between slimming or maintenance regimens. Conclusions: Major weight loss is associated with sustained and marked improvements in blood lipids and hemostatic pro®le, irrespective of the tested slimming and maintenance regimens.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects

Marckmann¹,

Toubro²,

Astrup³

1998

Eur J Clin Nutr

View full text Add to dashboard Cite

show abstract

“…Bahadori et al, (1996) have reported that close to 40% of obese angina patients do not have significant coronary artery disease, and so a clinical benefit from weight loss could be expected without necessarily modifying atheroma. Some previous studies have shown that weight reduction improves established measurements of coagulation, rheology and fibrinolysis Palareti et al, 1994). Most studies used short-term very low calorie diet (VLCD) regimens in otherwise healthy subject groups, where effects from acute, severe energy restriction are likely to confound any effects of weight loss per se.…”

Section: Introductionmentioning

confidence: 99%

Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris

et al. 2002

View full text Add to dashboard Cite

Objective: To evaluate the effects of moderate weight loss, in overweight patients with angina, on plasma coagulation, fibrinolytic indicies and pain frequency. Conclusions: A conventional dietetic intervention, resulting in 4% weight loss, offers the potential to reduce atherosclerotic and thrombotic risk, and to reduce pain frequency, in angina patients. Given the importance of this result in a public health context, these results indicate that this may be a fruitful area for future nutrition research.

show abstract

Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss

et al. 2001

View full text Add to dashboard Cite

Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of tissue-type plasminogen activator and has an important role in regulating the fibrinolytic system and thrombus formation. Higher plasma PAI-1 concentrations impair fibrinolysis, which could account for its predictability for cardiovascular events [1,2]. Obesity, an independent risk factor for cardiovascular diseases is associated with increased plasma PAI-1 values [3,4].The mechanisms involved in increased PAI-1 production in obesity have not been fully explained. The insulin-resistance syndrome, a cluster of metabolic abnormalities, accompanying visceral types of obesity could be an important regulator of PAI-1 expression. Indeed, all the variables related to the insulin resistance syndrome (insulinaemia, BMI, waistto-hip ratio (WHR), serum triglyceride and HDL cholesterol concentration) are strongly related to Diabetologia (2001 Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss Abstract Aims/hypothesis. Abdominal fat produces plasminogen activator inhibitor-1 (PAI-1) and could contribute to increased plasma PAI-1 values in human obesity associated with insulin resistance. Femoral fat, which is not associated with insulin resistance, is thought to be metabolically different from the abdominal fat. This study aimed to assess PAI-1 expression in these two fat territories in obese and lean subjects and to determine if concomitant changes of plasma and adipose tissue PAI-1 values occur after weight reduction.Methods. In 24 obese and 16 lean subjects, PAI-1 expression in abdominal and femoral subcutaneous fat, plasma PAI-1, insulin, triglyceride concentrations and insulin resistance were determined at the start of the study and in obese subjects after a 3-month weight reduction programme as well.Results. PAI-1 mRNA content in the abdominal subcutaneous fat was higher in obese than in lean subjects and positively correlated with plasma PAI-1 values (p < 0.01) and markers of insulin resistance (p < 0.05). In 18 obese subjects, re-examined after successful dieting, PAI-1 mRNA content decreased in the abdominal subcutaneous fat along with plasma PAI-1. However, the absolute changes of these two variables were not associated. In contrast, PAI-1 mRNA content in the femoral subcutaneous fat did not differ between lean and obese subjects, was not associated with plasma PAI-1 values or with markers of insulin resistance, and did not change after weight loss. Conclusion/interpretation. Only the abdominal, but not the femoral subcutaneous fat PAI-1 expression is a potential contributor to increases in plasma PAI-1 in obesity. Both plasma and abdominal subcutaneous fat PAI-1 values decreased significantly after weight reduction, although their absolute changes were not associated. [Diabetologia (2001

show abstract

Prolonged very low calorie diet in obese subjects reduces factor VII and PAI but not fibrinogen levels

Cited by 12 publications

References 23 publications

Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects

Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects

Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris

Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss

Contact Info

Product

Resources

About