Pancreatic Exocrine Carcinoma Producing Adrenocorticotropic Hormone

Gullo, Lucio; Giorgio, Roberto De; D’Errico, Antonietta; Grigioni, Francesco; Parenti, M; Corinaldesi, Roberto

doi:10.1097/00006676-199203000-00007

Cited by 12 publications

(4 citation statements)

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“…In our patient we were able to obtain tissue only from liver biopsy which proved a positive ACTH-containing cells conceivably related to the original pancreatic tumor. As previously reported, the ACTH immunoreactive component is mixed with a subpopulation of non-secreting cells, which is a common finding in this type of PNETs (24). A further feature of this case was the severe cortisol-dependent immunosuppression, which was a critical factor leading to the rapidly patient death.…”

Section: Discussionsupporting

confidence: 69%

An acute and severe immunodeficiency syndrome due to a pancreatic ACTH-producing tumor

et al. 2012

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We report a case of a 48 years old woman, with a rapidly progressing ACTH neuroendocrine tumor of the pancreas(PNET) and multiple liver metastases. The patient had previously suffered from peptic ulcer responsive to PPI inhibitors and hypertension poorly controlled by therapy. Admitted to the hospital for severe asthenia and abdominal pain, she was diagnosed poorly differentiated PNET with liver metastases, which were positive for synaptophysin, cytokeratin 7 and 9, neuron specific enolase (NSE). Octreoscan scintigraphy was positive for somatostatin receptor in the pancreatic and in two liver lesions. A rapidly progressive Cushing syndrome developed, presenting with the classical physical symptoms , hypokal emia and Lysteria Monocytogenes meningitis. An ectopic ACTH production was confirmed and eventually the patient died of a septic shock within two months. The case reported focuses on the malignity and the rapid progression of a PNET producing ACTH and alerts on the possible fatal progression of these cases

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Section: Discussionsupporting

confidence: 69%

An acute and severe immunodeficiency syndrome due to a pancreatic ACTH-producing tumor

et al. 2012

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“…Identical IHC pattern was detected in the metastatic tumors. A diffuse reaction to CgA observed in the neoplastic cells was associated with neuroendocrine differentiation of the neoplasm; this feature has been noted in some exocrine pancreatic adenocarcinomas in humans (Gullo et al, 1992;Pour et al, 1993). In addition, the negative reactions with antibodies to insulin, glucagon, somatostatin and gastrin excluded the diagnosis of endocrine or neuroendocrine carcinoma or gastrinoma.…”

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confidence: 74%

Metastatic exocrine pancreatic adenocarcinoma in a giant otter (Pteronura brasiliensis)

Pinto

Braga

Blume³

et al. 2023

AVet

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Neoplasms of the exocrine pancreas are uncommon in domestic animals and rarely occur in wildlife. This article describes the clinical and pathological findings of one case of metastatic exocrine pancreatic adenocarcinoma in an 18-year-old giant otter (Pteronura brasiliensis) in captivity with a history of inappetence and apathy. Abdominal ultrasonography was inconclusive, and tomography revealed a neoplasm affecting the urinary bladder and hydroureter. During the anaesthesia recovery, the animal presented a cardiorespiratory arrest and died. Grossly, there were neoplastic nodules in the pancreas, urinary bladder, spleen, adrenal glands, and mediastinal lymph node. Microscopically, all nodules were composed of a malignant hypercellular proliferation of epithelial cells with acinar or solid disposition, supported by a sparse fibrovascular stroma. Neoplastic cells were immunolabeled with antibodies to Pan-CK, CK7, CK20, PPP and chromogranin A. Approximately 25% of the cells were positive for the presence of Ki-67 too. Pathological and immunohistochemical findings confirmed the diagnosis of metastatic exocrine pancreatic adenocarcinoma.

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“…8 -10 In addition, there have also been some reports 11,12 of using PET or PET/CT scans to detect ectopic ACTH-secreting tumors. However, ectopic ACTH-secreting tumors in the pancreas are rarely seen, 13 and to our best knowledge, the descriptions of an ectopic ACTH-secreting tumor in the pancreas by PET/CT has not been reported in English publications.…”

Section: Figurementioning

confidence: 86%

Adrenocorticotropic Hormone–Secreting Tumor in the Pancreas Identified by PET/CT

Wang²,

Liu³

et al. 2012

Clinical Nuclear Medicine

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A 51-year-old woman presented typical symptoms of a Cushing syndrome. MRI scanning of the pituitary gland showed possible enlargement of the right side of the pituitary gland, suggestive of microadenoma. However, a transsphenoidal pituitary tumor resection failed to relieve the symptoms. An FDG PET/CT was performed to further evaluate this patient, which revealed abnormal FDG activity in the pancreas. After the surgical removal of the pancreatic lesion, the patient's symptoms disappeared. The pathologic examinations confirmed the lesion to be an adrenocorticotropic hormonesecreting neuroendocrine tumor.

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Pancreatic Exocrine Carcinoma Producing Adrenocorticotropic Hormone

Cited by 12 publications

References 0 publications

An acute and severe immunodeficiency syndrome due to a pancreatic ACTH-producing tumor

An acute and severe immunodeficiency syndrome due to a pancreatic ACTH-producing tumor

Metastatic exocrine pancreatic adenocarcinoma in a giant otter (Pteronura brasiliensis)

Adrenocorticotropic Hormone–Secreting Tumor in the Pancreas Identified by PET/CT

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