Diuretic Activity of Chlorothiazide Derivatives

Logemann, W.; Giraldi, P. N.; Parenti, M

doi:10.1038/1821510a0

Cited by 15 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…XI1 has been introduced as a diuretic under the trade name Salamid (Ferrosan) [37]. Also its 1,3-dimethyl derivative (R1, R3 = CH3; R2, R4, R5 = H; R6 = Cl) is highly active [38].…”

Section: Many Of These Compounds Have Diuretic Activity In Order To mentioning

confidence: 99%

Recent Developments in Non‐Mercurial Diuretics

Schlittler¹,

deStevens²,

Werner³

1962

Angew. Chem. Int. Ed. Engl.

View full text Add to dashboard Cite

carbonium character. However, conjagation of the carbonyl group with the developing double bond should, in terms of the E 2 mechanism, provide a strong driving force. This should be especially powerful in elimination from XX because conjugation of -zwith -CO-would be established in the transition state. Moreover, these reactions conform to the trans-stereoelectronic pattern characteristic of E 2 reactions [60,61]. [60] H. B. ilther and T. Reichstein, Helv. Chim. Acta 26, 492 (1943); E. Seebeck and T . Reichstein, ibid. 26, 536 (1943). [61] N.

show abstract

“…XI1 has been introduced as a diuretic under the trade name Salamid (Ferrosan) [37]. Also its 1,3-dimethyl derivative (R1, R3 = CH3; R2, R4, R5 = H; R6 = Cl) is highly active [38].…”

Section: Many Of These Compounds Have Diuretic Activity In Order To mentioning

confidence: 99%

Recent Developments in Non‐Mercurial Diuretics

Schlittler¹,

deStevens²,

Werner³

1962

Angew. Chem. Int. Ed. Engl.

View full text Add to dashboard Cite

show abstract

“…We have made another contribution to the problem (Logemann, Giraldi & Parenti, 1958, 1959Giraldi & Parenti, 1960) by the synthesis of methylated sulphonamides (III and IV) possessing a diuretic action. Unlike compounds I and II, compounds III and IV are not in vitro inhibitors of carbonic anhydrase, since inhibition of the enzyme is specifically connected with the presence of an unsubstituted sulphonamidogroup (Mann & Keilin, 1940).…”

Section: I~~~~~~~ivmentioning

confidence: 99%

On the Metabolism of Methylated Disulphonamides With a Diuretic Action—a Contribution to the Mechanism of Action of Chlorothiazide and Similar Compounds

Logemann¹,

Giraldi²

1962

British Journal of Pharmacology and Chemotherapy

Self Cite

View full text Add to dashboard Cite

The metabolism of two substances possessing a diuretic action, 4‐amino‐6‐chloro‐benzene‐1,3‐disulphonmethylamide (III) and 6‐chloro‐3,4‐dihydro‐2‐methyl‐7‐methyl‐sulphamoyl‐2H‐1,2,4‐benzo[e]thiadiazine‐1,1‐dioxide (IV), has been studied on rats and human subjects. It has been shown that these compounds are not demethylated in the –SO2.NHCH3 group. They therefore do not act through liberation of substances with unsubstituted sulphonamido‐groups which might inhibit carbonic anhydrase, and their mechanism of diuretic action cannot be considered due to inhibition of this enzyme.

show abstract

Effects of Drugs on Active Transport

Beyer

Baer

1962

Ciba Foundation Symposium ‐ Enzymes and Drug Action

View full text Add to dashboard Cite

Diuretic Activity of Chlorothiazide Derivatives

Cited by 15 publications

References 2 publications

Recent Developments in Non‐Mercurial Diuretics

Recent Developments in Non‐Mercurial Diuretics

On the Metabolism of Methylated Disulphonamides With a Diuretic Action—a Contribution to the Mechanism of Action of Chlorothiazide and Similar Compounds

Effects of Drugs on Active Transport

Contact Info

Product

Resources

About