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Superparamagnetic iron oxide particles embedded in silica are studied for application in hyperthermia. The temperature increase is studied when submitting the samples to a weak alternating magnetic field. The influence of the iron oxide size distribution, saturation magnetization, out of phase susceptibility and anisotropy constant is discussed. A theoretical calculation of power loss is carried out and agrees with experimental data.

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Magnetic nanoparticles possess many characteristics that make them promising as drug carriers and for use in biomedical applications. They can be attracted or magnetically guided by strong magnetic fields, thus acting as drug carriers. They can also be used for hyperthermia applications, due to the heat they produce in an alternating magnetic field. The resulting temperature increase can be used to modify or inhibit specific cell activities locally, or even to release drugs in a precisely controlled, temperature-increase activated manner. Magnetic nanoparticles can also serve as contrast agents for diagnostic applications such as magnetic resonance imaging.

Nanoscaled particles showing a superparamagnetic behavior have been intensively studied these past years for biomedical applications and water-based ferrofluids turned out to be promising candidates for various in vivo as well as in vitro applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large-scale synthesis of particles with a narrow size distribution. In this work iron oxide nanoparticles are obtained by classical co-precipitation in a water-based medium and are subsequently coated with polyvinyl alcohol. The thus obtained ferrofluids are studied and a focus is made on their colloidal stability.

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