Superparamagnetic Silica‐Iron Oxide Nanocomposites for Application in Hyperthermia

Chastellain, M.; Petri, A.; Gupta, Amita; Rao, K. V.; Hofmann, Heinrich

doi:10.1002/adem.200300574

Cited by 89 publications

(62 citation statements)

References 24 publications

(32 reference statements)

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“…poly(ethylene glycol)) (Lutz et al, 2006), dextran or poly(vinyl alcohol) (Liu et al, 2008), or alternatively a layer containing metals (like gold (Jeong et al, 2006)), non-metals (like graphite (Seo et al, 2006)) or oxides (silica (Chastellain et al, 2004)) deposited on its surface. ii) Magnetic colloids may be encapsulated thanks to polymers which protect them from further cluster growth and keep them separated beyond the range of attractive forces (Arias et al, 2011b;Lecommandoux et al, 2006).…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…For example, many of the particles used are superparamagnetic that can be easily magnetized with an external magnetic field, and when the field i s r e m o v e d , t h e y d o n o t e x h i b i t r e s i d u a l magnetization. If exposed to an alternating magnetic field, the iron oxide particles become powerful heat sources by transforming the energy from the magnetic field into heat (Chastellain et al, 2004;Jordan et al, 1997). The most important characteristic of magnetic nanoparticles for heat generation is particle size (Kalambur et al, 2005).…”

Section: Advances In Diverse Industrial Applications Of Nanocompositementioning

confidence: 99%

Multifunctional Nanocomposites Based on Mesoporous Silica: Potential Applications in Biomedicine

Sousa¹,

Souza²,

Mohallem³

et al. 2011

Advances in Diverse Industrial Applications of Nanocomposites

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“…The micron-sized particles had a density of 2.12 AE 0.02 gÁcm À3 at 25 C. They were synthesized as described by Chastellain et al [15]. Briefly, tetramethoxysilane (45 mL) was added to a 2 M solution of Fe(NO 3 ) 3 Á 9H 2 O in ethanol (44.4 g iron salt in 55 mL ethanol).…”

Section: Magnetics Beadsmentioning

confidence: 99%

Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model

Renard

Buchegger

Petri‐Fink

et al. 2009

International Journal of Hyperthermia

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Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden.The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Methods: We evaluated heating and treatment efficacies by means of thermometry and survival studies in nude mice carrying subcutaneous human colocarcinomas. At day 1, we injected the formulation into the tumor. At day 2, a single 20-min hyperthermia treatment was delivered by 141-kHz magnetic induction using field strengths of 9 to 12 mT under thermometry.Results: SPIONs embedded in silica microbeads were effectively confined within the implant at the injection site. Heat-induced necro-apoptosis was assessed by histology on day 3. On average, 12 mT resulted in tumor temperature of 47.8 C, and over 70% tumor necrosis that correlated to the heat dose (AUC ¼ 282 CÁmin). In contrast, a 9-mT field strength induced tumoral temperature of 40 C (AUC ¼ 131 CÁmin) without morphologically identifiable necrosis. Survival after treatment with 10.5 or 12 mT fields was significantly improved compared to non-implanted and implanted controls. Median survival times were 27 and 37 days versus 12 and 21 days respectively. Conclusion: Five of eleven mice (45%) of the 12 mT group survived one year without any tumor recurrence, holding promise for tumor therapy using magnetically induced moderate hyperthermia through injectable implants.

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Superparamagnetic Silica‐Iron Oxide Nanocomposites for Application in Hyperthermia

Cited by 89 publications

References 24 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Multifunctional Nanocomposites Based on Mesoporous Silica: Potential Applications in Biomedicine

Local moderate magnetically induced hyperthermia using an implant formed in situ in a mouse tumor model

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