Superparamagnetic Iron Oxide Nanoarticles for Biomedical Applications: a focus on PVA as a coating

Abstract

Nanoscaled particles showing a superparamagnetic behavior have been intensively studied these past years for biomedical applications and water-based ferrofluids turned out to be promising candidates for various in vivo as well as in vitro applications. Nevertheless, the lack of well-defined particles remains an important problem. One of the major challenges is still the large-scale synthesis of particles with a narrow size distribution. In this work iron oxide nanoparticles are obtained by classical co-precipitation in a water-based medium and are subsequently coated with polyvinyl alcohol. The thus obtained ferrofluids are studied and a focus is made on their colloidal stability.

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

“…used the ATRP method to synthesize polystyrene-coated iron oxide nanoparticles using divinylbenzene as a cross-linker 188 . Several other polymers, including polyvinyl alcohol (PVA) 189 , polyvinyl pyrrolidine (PVP) 190 , and polyacrylic acid 191 , were described as coating materials for iron oxide nanoparticles. These polymers provided a steric barrier to prevent nanoparticle agglomeration and enhance the blood circulation time.…”

Magnetic nanoparticles and their applications in image-guided drug delivery

“…Dextrans are also widely used surface-shielding materials, and several clinically approved MRI contrast agents are prepared by dextran coating [26][27][28]. Other polymers, such as polyvinyl alcohol [29], polyvinyl pyrrolidine [30], polyacrylic acid [31], and monomeric species, including bisphosphonates [32], dimercaptosuccinic acid [33], and alkoxysilanes [34], have been evaluated as coating materials for use in preventing nanoparticle agglomeration and enhancing blood circulation time. Recently, a new class of non-biofouling zwitterionic materials (macroscopically neutral with a net zero charge) was Fig.…”