Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

Abstract

Nanomaterials offer new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions including targeting, imaging, therapy, and etc have been intensively studied aiming to overcome limitations associated with conventional cancer diagnosis and therapy. Of various nanoparticles, magnetic iron oxide nanoparticles with superparamagnetic property have shown potential as multifunctional nanoparticles for clinical translation because they have been used asmagnetic resonance imaging (MRI) constrast agents in clinic and their features could be easily tailored by including targeting moieties, fluorescence dyes, or therapeutic agents. This review summarizes targeting strategies for construction of multifunctional nanoparticles including magnetic nanoparticles-based theranostic systems, and the various surface engineering strategies of nanoparticles for in vivo applications.

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

“…In addition to their small size, spherical shape, biocompatibility, and lack of susceptibility to photobleaching, their extinction peaks can be easily tuned to the NIR [60,78,79,221]. Additionally, the enhanced near field energy associated with their surface plasmon resonance and thin shells, which produce high absorption cross-sections, makes them ideal nanostructures for PTA.…”

“…The technique employs a NIR light trigger to facilitate site specific silencing through biomolecule delivery and the conversion of electronic energy to heat [245][246][247]. Nanocarriers typically target proteins, peptides, nucleic acids, DNA, and RNA [71,241,[248][249][250][251][252][253].…”

Study on the use of 3‐aminopropyltriethoxysilane and 3‐chloropropyltriethoxysilane to surface biochemical modification of a novel low elastic modulus Ti–Nb–Hf alloy

“…This problem can be overcome, at least in part, by adding a preliminary activation treatment. For pure titanium, there is a large diversity of examples in the literature suggesting different activation methods to provide reactive groups for covalent immobilization of biomolecules (mainly -OH groups) [2][3][4][5][6][7][8][9][10][11] and organosilanes bearing different functional groups [12][13][14][15][16][17]. Recently, a comparative study between two activation methods frequently used (Oxygen plasma and Piranha solution) was performed by V. Paredes [18].…”

“…Nowadays, organosilane precursors bearing functional groups such as amino [12][13][14][15][16][17][18][19][20][21][22], thiol, carboxyl, phosphate, vinyl [23][24][25], cyanide [26], phenyl [24,27] or sulphhydryl groups are readily available. Despite the wide variety of silane precursors available for surface modification, the majority of studies have employed aminosilanes, in particular 3-aminopropyltriethoxysilane (APTES) [11][12][13][14][15][16][17][18][19][20][21][22]. Nevertheless, the 3-chloropropyltriethoxysilane (CPTES) is also proposed by other authors [2,4,10].…”

Perspectives in Engineered Mesenchymal Stem/Stromal Cells Based Anti- Cancer Drug Delivery Systems

“…This "nano-carriers" as passive-targeted drug-loaded vehicles are still the predominant delivery systems used for cancer therapy. However, these systems have limitations in their use by tumor vascularization and permeability that are largely dependent on the stage of malignancy and tumor type [148].…”