Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Schulze, Katja; Koch, Annette; Schöpf, Bernhard; Petri, A.; Steitz, Benedikt; Chastellain, M.; Hofmann, Margarethe; Hofmann, Heinrich; Rechenberg, Brigitte von

doi:10.1016/j.jmmm.2005.02.075

Cited by 66 publications

(43 citation statements)

References 14 publications

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“…108 Polyvinyl alcohol-SPIONs and their fluorescently functionalized analogs, ie, amino-polyvinyl alcohol-Cy2.5 SPIONs, were injected intra-articularly or periarticularly in the stifle and carpometaphalangeal joints of sheep and targeted using a permanent NdFeB magnet. 109 The results confirmed the biocompatibility of these nanoparticles, which were found to remain within the synovial membrane for a period of 5 days, demonstrating their potential applicability in prolonging the action of medication applied intra-articularly. SPIONs and dexamethasone acetate coencapsulated into polylactic-co-glycolic acid microparticles can also serve as a targeted delivery system for the treatment of joint-related pathologies.…”

Section: Treatment Of Arthritissupporting

confidence: 68%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

889

574

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Section: Treatment Of Arthritissupporting

confidence: 68%

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Wahajuddin¹,

Arora²

2012

IJN

889

574

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“…The use of PVA-coated magnetic nanoparticles in biomedical applications has been reported (Schulze et al 2006). This research group has demonstrated the internalization of PVA and PVA co-polymer-coated magnetic nanoparticles by synoviocytes and by cells of the synovial membrane in sheep (Schulze et al 2005).…”

Section: Synthetic Organic Polymersmentioning

confidence: 99%

Magnetic nanoparticles for gene and drug delivery

McBain

Yiu²,

Dobson

2008

IJN

234

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Abstract:Investigations of magnetic micro-and nanoparticles for targeted drug delivery began over 30 years ago. Since that time, major progress has been made in particle design and synthesis techniques, however, very few clinical trials have taken place. Here we review advances in magnetic nanoparticle design, in vitro and animal experiments with magnetic nanoparticle-based drug and gene delivery, and clinical trials of drug targeting.

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“…There are some special kind of nanostructured materials like bio-magnetic nanoparticles which is important to consider the physico-chemical and electro-magnetic properties of nanostructured materials specially MNPs which will be composed at least magnetic element. So, these materials has attracted much interest which has been caused to extend wide range of applications like ferro fluid solutions, magnetic storage devices, bio-sensing application, magnetic power generations and conversion, magnetic controlled drug delivery, magnetic resonance imagining as a contrast agents [61][62][63][64][65][66][67][68][69][70][71][72][73][74]. For biomedical applications, magnetic nanoparticles must (1) have a good thermal stability; (2) larger magnetic moment; (3) be biocompatible; (4) be able to form stable dispersion so the particles could be transported in living system; and (5) well response to AC magnetic fields.…”

Section: Biomedical Applications Of Fe 3 O 4 Magnetic Nanoparticlesmentioning

confidence: 99%

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

Nochehdehi¹,

Thomas²,

Sadri³

et al. 2017

J Nanomed Nanotechnol

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Nanotechnology is a multidisciplinary branch of science which encompasses numerous diverse fields of science and technology, ranging from biomedical, pharmaceutical, agricultural, environmental, advanced materials, chemical science, physics, electronics, information technology, and so on. Physical and Chemical properties as a major advantages of Nanoparticles can be used in various applications from Industries to medicine. Besides, Magnetic nanoparticles for medical applications have been developed by many researchers. In recent decades, it has received attention by virtue of their potential for applications in different fields. Due to several advantages and widespread applications of magnetic Nanoparticles in biotechnology, medical, material science, engineering, and environmental areas, much attention has been paid to the synthesis of different kinds of Biomagnetic nanoparticles (BMNPs). Core-shell nanoparticles include of coated various materials like: biopolymers (Chitosan, PAA) and bioceramics (Hydroxyapatite) as a shell on top of them and different hard and soft materials like metal oxide (Iron oxide and Cob alt composite) as a core. Improved properties of core-shell nanoparticles like less cytotoxicity, increase biocompatibility, decrease in an interactions with biomolecules, increase physicochemical stability and sort of that, can be due to their use in biological applications. After reviewing several research and review articles and synthesis procedure of Iron based Bio-magnetic Nanoparticles (BMNPs), we should emphasize that, It can be used in different applications like magnetic resonance imaging (MRI), drug delivery systems (DDS), immunoassay, also specially in diagnosis and treatment of cancer via hyperthermia (heat therapy) method.

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Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep

Cited by 66 publications

References 14 publications

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Magnetic nanoparticles for gene and drug delivery

Iron Oxide Biomagnetic Nanoparticles (IO-BMNPs); Synthesis, Characterization and Biomedical Application–A Review

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