Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers

Abstract

A targeted drug delivery system is the need of the hour. Guiding magnetic iron oxide nanoparticles with the help of an external magnetic field to its target is the principle behind the development of superparamagnetic iron oxide nanoparticles (SPIONs) as novel drug delivery vehicles. SPIONs are small synthetic γ-Fe 2

Evaluation of Differences between Fe3O4 Micro- and Nanoparticles Properties

“…they behave like paramagnetics with a high magnetic susceptibility. As known, superparamagnetic properties of Fe 3 O 4 particles at room temperature are exhibited, when reaching an average diameter D < 25 nm [7,19,20]. In our case the particles size is 5-10 nm.…”

“…Superparamagnetic iron oxide nanoparticles with appropriate surface can be used to enhance the contrast of images, tissue repair, detoxification of biological fluids, hyperthermia, for the directed delivery of pharmaceuticals, and separation of cells. All the biomedical applications require that the * corresponding author; e-mail: kulykvolodymyrvolodymyrovych@gmail.com nanoparticles have high enough levels of saturation magnetization; their size should be less than 100 nm with a small deviation in size [7][8][9]. Depending on the sizes other properties of nanoparticles as toxicity, adsorption ability and magnetism also change.…”

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

“…For example, the ability of insoluble drugs combined with nanoparticles to increase drug uptake by malignant cells and control drug release in specific sites is significantly improved when compared with free drugs. [9] Various nanoparticles have been used in TDDSs such as solid lipid nanoparticles, [10] liposomes, [11] superparamagnetic nanoparticles, [12] and quantum dots. [13] Gold nanoparticles (AuNPs) are well suited to a range of medical applications due to their easy preparation and bioconjugation ability to bind to thiol groups and improved surface catalytic activity.…”

Synthesis, surface characterization and electrokinetic properties of colloidal silica nanoparticles with magnetic core

“…Core/shell hybrid materials can be composed of different core materials, which are characterized by many interesting properties, such as: magnetic (Hyeon 2002;Deng et al 2008;Kim et al 2008), fluorescence (Tovmachenko et al 2006;Reiss et al 2009), luminescent etc. Especially, superparamagnetic iron oxide nanoparticles (SPIONs) (Salgueirino-Maceira and Correa-Duarte 2007) are promising materials for many biomedical applications, such as hyperthermia treatment , magnetic resonance imaging (MRI) (Schlorf et al 2011), targeted drug delivery systems, especially in cancer treatment Rosena et al 2012;Wahajuddin and Arora 2012), magnetically removable catalysts and, more recently, as magnetically removable adsorbents (Tang and Lo 2013;Zhang et al 2008). Nevertheless, there is a need to modify their surface in order to improve their biocompatibility and biodegradability.…”