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Attempts to digitize samples and apply artificial intelligence and machine learning methods to analyze crystalloscopic (dried drops of biological fluids) and tesigraphic (dried drops of biological fluids with crystallogenic substance) facies have not yet been successful. In this regard, there is a need to develop a simplified algorithm for describing the facies of biological fluids, which can be used for a unified computer study of the results of crystallization of biological objects, which served as the purpose of the work. To develop and test the method presented in this paper, we used more than 16,000 images of dried biological fluids of the human and animal body, including both crystalloscopic and tesigraphic facies. The algorithm is based on determination of 4 main parameters (crystallizability, structure index, facies destruction degree and clearity of the marginal zone), graded on three-point scales. In addition, a facies integral parameter combining the values of all criteria is proposed.

The aim of the study was at the cohort assessment of microelement status in large city residents classified as “apparently healthy people”. The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender. A blood sample was taken once from each person to determine concentrations of microelements. The level of peripheral blood microelements were determined by atomic absorption spectrometry using «Shimadzu AA7000» device (Japan). The study of a large population of city residents demonstrated inhomogeneity in their microelement status. Deficit conditions were found for a number of values, including concentrations of potassium, sodium, nickel, stibium, chromium and cadmium. At the same time, there are large proportions of persons with low plasma concentrations of copper and even lower plasma concentrations of zinc and magnesium. On the contrary, 42% of the persons show high concentrations of lithium. Such disturbances of microelement homeostasis (pre-pathological condition) make it necessary to perform targeted correction for the purpose of preventing the development of pathological conditions associated with microelement deficiencies.

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