Cohort study of microelement status in “healthy” population of Russian megapolis

Abstract

The aim of the study was at the cohort assessment of microelement status in large city residents classified as “apparently healthy people”. The population study included 2,025 randomly selected middle-aged (2045 years) persons without chronic diseases or acute infectious pathologies. The set of subjects was standardized by age and gender. A blood sample was taken once from each person to determine concentrations of microelements. The level of peripheral blood microelements were determined by atomic absorption spectrometry using «Shimadzu AA7000» device (Japan). The study of a large population of city residents demonstrated inhomogeneity in their microelement status. Deficit conditions were found for a number of values, including concentrations of potassium, sodium, nickel, stibium, chromium and cadmium. At the same time, there are large proportions of persons with low plasma concentrations of copper and even lower plasma concentrations of zinc and magnesium. On the contrary, 42% of the persons show high concentrations of lithium. Such disturbances of microelement homeostasis (pre-pathological condition) make it necessary to perform targeted correction for the purpose of preventing the development of pathological conditions associated with microelement deficiencies.

Iron Metabolism Under Selective Individulized Correctio

“…Numerous epidemiological studies indicate, on the one hand, a sufficiently high frequency of iron deficiency anemia and associated pathological conditions [1][2][3] and, on the other hand, indicate a significant proportion of persons with subclinical manifestations of metabolic disorders of this trace element [6]. Thus, according to the results of our previous studies, up to 27% of the adult population of the metropolis have either fullfledged or subclinical (at the level of the lower quartile) serum iron deficiency [4]. These facts clearly indicate the feasibility of targeted detection and personalized correction of iron deficiency.…”