Bioradical homeostasis as new complex parameters of different biological systems

Oxidative stress in osteomyelitis and burns: Specific features of its role in development of pathology

“…It is known that oxidative stress is a universal pathological process (syndrome) that develops in various diseases and conditions [8][9][10][11][12][13][14][15][16][17] . Simultaneously, there is relatively little information about the specificity of changes in the balance of free radical processes and antioxidant systems in blood and tissues formed within the framework of oxidative stress in specific pathologies 1,4,5 . Therefore, this study attempted to establish the features of specificity for oxidative stress in traumatic pathologies (e.g.…”

“…Oxidative stress is seen in blood plasma and red blood cells, accompanied by a pronounced depletion of enzyme antioxidant system reserve. The findings of the oxidative stress features may prove useful in determining a different approach to the correction of pathological conditions, such as burns and osteomyelitis 5,25,[28][29][30] .…”

“…It is known that the reactions of free radicals and the opposing activity of a wide range of antioxidant systems are the fundamental basis for various aspects of the functioning of cells and tissues [1][2][3][4] . In particular, they contribute to the renewal of cellular structures and processes, including biological membranes, energy metabolism, and phagocytic reactions 1,[4][5][6][7] . All of these processes, combined with oxidative metabolism, can be utilized to disrupt underlying conditions of various pathologies 4,[8][9][10][11] .…”

“…This disruptive condition is called oxidative stress, and can be regarded as a complex universal syndrome 8,[12][13][14][15] . In the laboratory, signs of oxidative stress include a pronounced activation of free radical processes, accompanied by a significant inhibition of the corresponding blood and tissue systems 5,13,[15][16][17] . Indeed, despite confirmation in literature of the significant role of oxidative stress in the pathogenesis of various diseases, the specificity of its implementation in a particular pathology is still poorly understood.…”

Diagnostic algorithm for comorbidity of babesiosis and dirofilariasis in dogs, taking into account the correlation of redox homeostasis and morphofunctional disorders of the hepatorenal and cardiopulmonary systems

“…In addition, the classical clinical picture of many diseases undergoes changes and gradually loses its typicality, and the issue of comorbidity of diseases is the result of the existence of biological systems [4].In recent years, the problem of the development mechanism of the association of babesiosis and dirofilariasis remains open, and polymorphism of manifestations of canine babesiosis and the persistence of parasites is an important clinical problem, there are also many unresolved issues in the diagnosis of the disease, therapy and prevention of this mixed invasion [5].It has been established that the violation of the homeostatic mechanisms of redox homeostasis of the body [6] is the leading pathogenetic component in the development of morphofunctional disorders in comorbidity of babesiosis and dirofilariasis in dogs.…”