While the focus of the medical community is on the management of COVID-19 and its associated complex presentations, it is critical to recognize that patients will continue to present with other medical problems that require urgent therapeutic interventions. There is growing concern that such interventions might have an impact on the natural history of COVID-19. We present a case of a patient who presented with unstable angina and multivessel coronary artery disease for which coronary artery bypass surgery was indicated and performed. Unfortunately, he succumbed to respiratory complications attributed to COVID-19. Our experience suggests concern about adverse outcomes in patients undergoing cardiac surgery who might be infected with COVID-19. Clearly, additional investigations and experience are needed.
This paper discusses the case report on Mycoplasma infection in cat and its timely diagnosis by blood smear examination and haematology. It also discusses the treatment and response of the cat for the disease. Haemobartonellosis in cats is caused by Mycoplasma haemofelis, formerly known as Haemobartonella felis. An eight months old Persian cat was received in the Small Animal Clinics, Out Patient Ward, Medicine department, Madras Veterinary College with the history to suspect for feline Mycoplasmosis. Peripheral blood smear and whole blood sample was collected and subjected to blood smear examination and whole blood for routine haematological study. It revealed codocytosis, anisocytosis and hypochromasia. Few ghost cells also were seen. Nearly 80-85% of the RBCs revealed darkly stained small organism at the rim or periphery of the cells.
The genetic diversity and evolutionary origin of the Monkeypox virus (MPXV) that is currently creating a multi-country outbreak-2022 is not fully understood. Here we report that the MPXVs that cause outbreak-2022 (MPXVs-2022) have deletion/insertion of ~500 to 2000bp nucleotide in multiple genomic regions. Our analyses revealed that MPXVs-2022 are very close to the West African Clade of MPXVs (WA-MPXVs) that caused the Outbreak in Nigeria in 2017-2018. Furthermore, we classified the WA-MPXVs detected before 2017 that could not be transmitted from human-to-human as WA-MPXVs-I and WA-MPXVs detected after 2017 that could be transmitted from human-to-human as WA-MPXVs-II (including MPXVs-2022), and human-to-human transmissible Central African MPXVs (CA-MPXV) remained as a separate clade. Overall our results suggest that although WA-MPXVs-II are almost identical to WA-MPXVs-I throughout the genome and two large genomic insertions (~500, 2000bp size insertion), they differ from WA-MPXVs-I in 5'-inverted terminal repeat (5'-ITR) (deletion of the last-2000bp-5'-ITR) and 13 proteins that of CA-MPXVs, and the presence of seven unique proteins in WA-MPXVs-II is likely to be a significant cause of outbreak-2022. This study shed light on the genetic diversity and evolutionary origin of MPXVs causing outbreak-2022.
In the present study the comparative in-vitro and in-vivo efficacy of Go 10213 was compared with those of metronidazole, secnidazole, tinidazole, ornidazole and nimorazole against a metronidazole-resistant strain of T. vaginalis. Go 10213 was found to be superior in activity. It appears more promising than the drugs mentioned above on the basis of the evidence presented.
Justicia gendarussa Burm .f. (family Acanthaceae) which is also known as willow-leaves and commonly known as Nili-Nirgundi, it is very commonly found nearby to China and its availability is very common in larger parts of India and Andaman islands. Traditionally it is used to treat various sorts of disorders such as wound healing, anti-inflammatory, anti-oxidant, antiproliferative, anti-arthritic etc. Justicia gendarussa is one of the crucial herbs which has been used in the Ayurveda. Majorly leaves parts of the plant shows the pharmacological activity but the root of the plant Justicia gendarussa is also have the important medicinal values. A large variety of pharmacologically active constituents i.e., alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, aminoacids, tannins, phenolics, coumarines and anthaquinones are also present in this plant and they makes the plant pharmacologically important. The activity of the plant is also dependent on the solvent which is used for the extraction the various vital chemical constituents. The different- different parts of the plants having the different medicinal values also differ in the chemical values. This review is not only focused on the essential phytochemical constituents which is available in the plant but it also explains their necessary medicinal value to shows the essential biological action and phytopharmacological actions of various parts of the plant.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.