Comparative efficacy of metronidazole and another 5-nitroimidazole, CG-10213-Go, in caecal amoebiasis in albino mice (<i>Mus musculus</i>)

Ray, DW; Tendulkar, J. S.; Shrivastava, Vikas; Nagarajan, K.

doi:10.1093/jac/10.4.355

Cited by 11 publications

(4 citation statements)

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“…Satranidazole has been shown to possess superior activity as compared to metronidazole against cecal amebiasis in the mouse model [2] and in hamster model [3,8]. Satranidazole has also been shown to achieve higher concentration in liver in hamster models [8].…”

Section: Discussionmentioning

confidence: 99%

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Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

2006

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The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtime). Patients recorded side effects and tolerability through a performa. The time taken for resolution of fever and pain and the fall in abscess size was not significant. However, tolerance of satranidazole as reported by the patients was significantly better than metronidazole (P < .005). The incidence of adverse effects was significantly lower in the group given satranidazole (P < .005). The incidence of nausea and metallic taste was significantly lower in the patients given satranidazole (P < .005). Thus, despite having a similar efficacy, satranidazole showed a far lower incidence of side effects and had a significantly better tolerance than Metronidazole.

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Section: Discussionmentioning

confidence: 99%

“…It possesses superior activity to metronidazole against cecal amebiasis in the mouse model [2] and in the hamster model [3]. Satranidazole has been shown to damage DNA as a consequence of reduction of the nitro group [4].…”

Section: Introductionmentioning

confidence: 99%

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

2006

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“…Although, attempts have also been made to establish caecal amoebiasis in albino mouse (Neal andHarris 1975, Gold andKagan 1978), the variability in infection rate and development of lesions usually make this model unsuitable for drug screening. However, Ray et al (1982) claimed to have produced uniform infection in mice by purging the animals with magnesium sulphate prior to the infection, and used this model for screening potential amoebicides. In this study, monoxenic E. histolytica trophozoites were inoculated intra-caecally in the Swiss albino mice.…”

Section: Findings Of Histopathologymentioning

confidence: 99%

Caecal-inoculation of entamoeba histolytica in the immunodepressed swiss albino mice treated with Cyclophosphamide

Faruqui

Khanum

Haq

et al. 2014

J Bangladesh Acad Sci

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A total of 72 mice were used for an experimental model of intestinal amoebiasis developed in the Swiss albino mice dividing into three groups, experimental immunocompetent mice group (Group-A), experimental immunodepressed mice group (Group-B) and control group (Group-C).The inoculum (10 6 cells of Entamoeba histolytica/0.2 ml of medium) was used to inoculate into the caecum of the experimental groups of mice in the ICDDR,B laboratory, Dhaka. The mice were sacrificed at 5, 10, 15, 20, 25 and 30 th days after inoculation for observation of caecal lesions and gross pathologic changes and histopathological analysis. The animals in the experimental two groups and control did not develop any caecal amoebiasis. The culture results of the stool of the mice which were inoculated with the inoculum of E. histolytica were found to be positive on the first 10 days after post caecal inoculation. After 10 days, the culture results were negative and the antiamoebic antibody levels of all animals were also found negative.

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“…SZ, (1-methylsulphonyl-3-[1-methyl-5-nitro-2-imidazolyl]-2-imidazolidinone) is a novel nitroimidazole which differs from other 5-nitroimidazoles such as MTZ, ornidazole, and tinidazole, in that the 2°C of the imidazole ring is connected through nitrogen to a substituted imidazolidinone moiety. [ 16 ] It possesses similar activity as MTZ against cecal amebiasis in the mouse model[ 17 ] and in the hamster model. [ 18 ] SZ has been shown to damage DNA as a consequence of the reduction of the nitro group.…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

et al. 2015

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Aim:The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.Materials and Methods:Seventy subjects with probing depth (PD) ≥5 mm were selected. Thirty-five subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index, gingival index, clinical attachment level (CAL), and PD at baseline; 1 month, 3 months, and 6 months interval. Furthermore, microbial analysis using polymerase chain reaction was done to estimate the number of sites harboring periodontopathogens.Results:Sixty four subjects were evaluated up to 6 months. At 6 months, the Group 2 resulted in greater mean reduction (4.10 mm) in PD as compared to Group 1 (1.49 mm), and also a greater mean CAL gain (4.20 mm) in Group 2 as compared to Group 1 (1.13 mm). These subjects also showed a significant reduction in the number of sites harboring periodontopathogens.Conclusion:The use of 3% SZ gel, when used as an adjunct to nonsurgical periodontal therapy in subjects with periodontitis, achieved better results than initial periodontal treatment alone.

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Comparative efficacy of metronidazole and another 5-nitroimidazole, CG-10213-Go, in caecal amoebiasis in albino mice (Mus musculus)

Cited by 11 publications

References 0 publications

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

Caecal-inoculation of entamoeba histolytica in the immunodepressed swiss albino mice treated with Cyclophosphamide

Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

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