We aimed to evaluate the effect of anti-diabetic activity of Terminalia arjuna, and Syzygium cumini extracts in Streptozotocin (STZ) induced diabetes in Wistar rats. STZ (55mg/kg) followed by nicotinamide (100mg/kg) was given to rats by intraperitoneal route to induce diabetes. Oral administration of alcoholic and hydro-alcoholic extracts of T. arjuna (TAAE) (250mg/kg and 500mg/kg), S. cumini (SCAE) (200mg/kg and 400mg/kg) and their composite extract were given to rats along with standard anti-diabetic drug Glibenclamide (5mg/kg). We evaluated body weight, glucose level, lipid profile and biochemical parameters in STZ induced diabetic rats. Also, histopathological studied were done in liver, kidney and pancreatic tissues of rats. Our finding revealed that TAAE and TAHE at 250mg/kg b.w. and 500mg/kg b.w., SCAE and SCHE at 400mg/kg b.w. and combination of TAAE (250mg/kg b.w.)+SCAE (400mg/kg b.w.) had a positive effect in lowering the blood glucose level and body weight on 28th day as compared to the initial observation on 0th day and also restored all the biochemical parameters such as LDL, VLDL, triglycerides and total Cholesterol and HDL towards the normal levels as well as histopathological improvement in Kidney, Liver and Pancreas. Data analysis showed that composite extract of TAAE (250mg/kg) and SCAE (400mg/kg ) improved diabetic consequences more effectively than composite extract of TAHE (500mg/kg) and SCHE (400mg/kg). TAAE and SCHE, in combination, demonstrate as a potential therapeutic agent against diabetes.
Punica granatum (PG) Linn (Family Punicaceae) is also known as pomegranate in English and commonly known as Anar in Hindi, it is found in the nearby region of Iran and very often found in the Himalayas and northern region of India and also cultivated since the ancient times, all over the region of Africa, Europe, and Asia. The various parts of pomegranate plants like seeds, leaf, root, and rind, in the traditional medicine system, used to treat multiple disease ailments such as wound healing, antioxidant, anti-inflammatory, decreases cancer risks, anti-arthritic, anti-proliferative and many more diseases.Punica granatum Linn. f. has an excellent level of pharmacological action, which very important according to the medicinal point of view. An enormous variety of phytochemicals such as alkaloids, flavonoids, saponin, carbohydrates, steroids, triterpenoids, carotenoids, amino acids, tannins, phenolics, and coumarins. This plant (PG) is very rich in phenolic compounds, due to the presence of such a wide variety of phytoconstituents. The whole plant was extensively used during the holistic medicine system in the treatment of the number of disease treatment.This review mainly focused on the large variety of essential pharmacognostic and pharmacological profile that is necessary to exhibit the crucial therapeutic activity and phytopharmacological properties of different parts of Punica granatum.
Diabetes mellitus (DM), belongs to the class of metabolic diseases having the primary symptom associated with this disease is high sugar levels in the blood for an extended period. It can be categorized to the world's major diseases considering that affects the high population on the earth and presents two main types I and II.The prevalence of diabetes for all age-groups world-wide was estimated to be 2.8% in 2000 and 4.4% in 2030. Diabetes complications include possible blindness, amputation of a lower limb, renal failure, and cardiac arrest or stroke. There are twenty types of Pramehas (Kaphaja-10 Pittaja-6, and Vataja-4) have been mentioned in the Ayurveda. ‘Prameha’ and ‘Diabetes’ are synonymous. Diabetes is one of the ‘Prameha’ which consists of two words, ‘Pra’ meaning abundant, and ‘Meha' meaning 'passing of large quantity of Urine. Incidentally, the term diabetes has been derived from the Greek term 'Diabainein' to mean 'to cross through a siphon' meaning the continuous free flow of water and applied to mean the elimination of large quantity of Urine. Thus the terms ‘Prameha’ and ‘Diabetes’ carry similar meaning. This review summarizes the two Ayurvedic formulations for both types of DM, which are mentioned in the Ayurvedic Formulary of India. Till now, various kinds of synthetic and herbal formulations were made, and many are more frequently used to achieve desirable treatment. Patients prefer oral anti-diabetic medications since they are more comfortable to be administered, and for this reason, researchers focus their studies in this direction. This review aimed to explore the possibility of anti-diabetic treatment from herbal sources well mentioned in Ayurvedic Formulary of India that is Avipattikara Churna, Triphala Churna.Triphala Churna
Increased blood lipid profile (hyperlipidaemia) has been described as a significant risk factor, which is majorly responsible for making the coronary heart diseases more severe. Coronary heart disease, stroke, atherosclerosis and hyperlipidaemia are the primary cause of death. The increase in total cholesterol and total low-density lipoprotein (LDL) cholesterol is described for its main risk factor, which is responsible for cardiovascular disease. The anti-hyperlipidemic drugs are used frequently for its lipids lowering potential to protect disorders which are induced by a condition like atherosclerosis. Still, these hypolipidemic agents also have various sorts of adverse events. Many plants and their derivatives and have been tested successfully for their anti-hyperlipidemic role. Almost 70 medicinal plants and more than this have been successfully screened for their significant anti-hyperlipidemic role. The significant increase observed in the use of medicinal plants in metropolitan regions of developed countries in the last decades. There are so many medicinal plants play a crucial role in lowering the blood lipid level. The most important advantage and popularity of traditional medicine system are because of effectiveness, safety, affordability and acceptability. This review focus on the anti-hyperlipidemic role of Avipattikar Churna and Triphala Churna used for the treatment of hyperlipidaemia.
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