While the focus of the medical community is on the management of COVID-19 and its associated complex presentations, it is critical to recognize that patients will continue to present with other medical problems that require urgent therapeutic interventions. There is growing concern that such interventions might have an impact on the natural history of COVID-19. We present a case of a patient who presented with unstable angina and multivessel coronary artery disease for which coronary artery bypass surgery was indicated and performed. Unfortunately, he succumbed to respiratory complications attributed to COVID-19. Our experience suggests concern about adverse outcomes in patients undergoing cardiac surgery who might be infected with COVID-19. Clearly, additional investigations and experience are needed.
This paper discusses the case report on Mycoplasma infection in cat and its timely diagnosis by blood smear examination and haematology. It also discusses the treatment and response of the cat for the disease. Haemobartonellosis in cats is caused by Mycoplasma haemofelis, formerly known as Haemobartonella felis. An eight months old Persian cat was received in the Small Animal Clinics, Out Patient Ward, Medicine department, Madras Veterinary College with the history to suspect for feline Mycoplasmosis. Peripheral blood smear and whole blood sample was collected and subjected to blood smear examination and whole blood for routine haematological study. It revealed codocytosis, anisocytosis and hypochromasia. Few ghost cells also were seen. Nearly 80-85% of the RBCs revealed darkly stained small organism at the rim or periphery of the cells.
The genetic diversity and evolutionary origin of the Monkeypox virus (MPXV) that is currently creating a multi-country outbreak-2022 is not fully understood. Here we report that the MPXVs that cause outbreak-2022 (MPXVs-2022) have deletion/insertion of ~500 to 2000bp nucleotide in multiple genomic regions. Our analyses revealed that MPXVs-2022 are very close to the West African Clade of MPXVs (WA-MPXVs) that caused the Outbreak in Nigeria in 2017-2018. Furthermore, we classified the WA-MPXVs detected before 2017 that could not be transmitted from human-to-human as WA-MPXVs-I and WA-MPXVs detected after 2017 that could be transmitted from human-to-human as WA-MPXVs-II (including MPXVs-2022), and human-to-human transmissible Central African MPXVs (CA-MPXV) remained as a separate clade. Overall our results suggest that although WA-MPXVs-II are almost identical to WA-MPXVs-I throughout the genome and two large genomic insertions (~500, 2000bp size insertion), they differ from WA-MPXVs-I in 5'-inverted terminal repeat (5'-ITR) (deletion of the last-2000bp-5'-ITR) and 13 proteins that of CA-MPXVs, and the presence of seven unique proteins in WA-MPXVs-II is likely to be a significant cause of outbreak-2022. This study shed light on the genetic diversity and evolutionary origin of MPXVs causing outbreak-2022.
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