Comparative studies on the amoebicidal activity of known 5-nitroimidazole derivatives and CG 10213-Go in golden hamsters, <i>Mesocricetus auratus</i>, infected in the liver or caecum or both with trophozoites of <i>Entamoeba histolytica</i>

Ray, DW; Shrivastava, Vikas; Tendulkar, J. S.; Dutta, A. K.; Bhopale, Kamlesh K.; Chatterjee, D. K.; Nagarajan, K.

doi:10.1080/00034983.1983.11811709

Cited by 17 publications

(6 citation statements)

References 5 publications

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“…Satranidazole has been shown to possess superior activity as compared to metronidazole against cecal amebiasis in the mouse model [2] and in hamster model [3,8]. Satranidazole has also been shown to achieve higher concentration in liver in hamster models [8].…”

Section: Discussionmentioning

confidence: 97%

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Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

2006

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The aims of our randomized, single-blind trial involving 49 patients were to study the efficacy, side effects, and tolerance of metronidazole and satranidazole in patients of amebic liver abscess. Twenty-five patients received metronidazole (800 mg TID) and 24 received satranidazole (300 mg TID with placebo at mealtime). Patients recorded side effects and tolerability through a performa. The time taken for resolution of fever and pain and the fall in abscess size was not significant. However, tolerance of satranidazole as reported by the patients was significantly better than metronidazole (P < .005). The incidence of adverse effects was significantly lower in the group given satranidazole (P < .005). The incidence of nausea and metallic taste was significantly lower in the patients given satranidazole (P < .005). Thus, despite having a similar efficacy, satranidazole showed a far lower incidence of side effects and had a significantly better tolerance than Metronidazole.

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Section: Discussionmentioning

confidence: 97%

“…It possesses superior activity to metronidazole against cecal amebiasis in the mouse model [2] and in the hamster model [3]. Satranidazole has been shown to damage DNA as a consequence of reduction of the nitro group [4].…”

Section: Introductionmentioning

confidence: 99%

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

2006

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“…Plusieurs modèles d'amibiase caecale utilisant une souche gnotoxénique d'Amibes ont été décrits chez le Rat (Neal et Harris, 1977 ;Singh et al, 1971), le Hamster (Ray et al, 1979(Ray et al, , 1981, le Cobaye (Anand et al, 1985). Avec les Cobayes et les Hamsters, la pathologie est moins sévère, plus inconstante et les Cobayes supportent moins bien l'infection que les Rats.…”

Section: -Discussionunclassified

Nouveau modèle expérimental d’amibiase cæcale chez le rat

Rigothier

Vuong

Gayral

1989

Ann. Parasitol. Hum. Comp.

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RÉSUMÉ. Le Raton a été utilisé comme modèle expérimental d'amibiase caecale, en pratiquant l'implantation, sans effraction du caecum, d'une suspension de trophozoites d'Entamaeba histo lytica, souche gnotoxénique Rahman, de virulence élevée. L'atteinte de la paroi est objectivée par l'aspect macroscopique du caecum, par la densité des trophozoites présents et par un examen anatomopathologique. Comme il existe une corré lation entre les paramètres macroscopiques et l'histologie, un indice de gravité est défini, qui prend en compte plusieurs critères macro-et microscopiques.Ce modèle permet donc de suivre les différentes phases de la cicatrisation et de la guérison des ratons et d'apprécier ainsi l'activité de substances antiamibiennes. Mots-clés : Entamaeba histolytica. Modèle in vivo. Pathologie. A new experimental model of caecal amibiasis in the rat.SUMMARY. The young rat was used as an experimental model of caecal amibiasis by implan ting, without injury of the caecum, a suspension of E. histolytica trophozoïtes gnotoxenic strain Rahman of high virulence.The degree of pathogenicity is demonstrated by the macroscopic aspect of caecum, by the density of trophozoites and by an anatomopathologie examination. As a correlation exits between all these macroscopic parameters and histology, a degree of illness is fixed which include several macro-and microscopic criteria. This model enables to observe the different phasis of cicatriza tion and of recovering of young rats and so to appreciate the activity of antimoebic agents.

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“…[ 16 ] It possesses similar activity as MTZ against cecal amebiasis in the mouse model[ 17 ] and in the hamster model. [ 18 ] SZ has been shown to damage DNA as a consequence of the reduction of the nitro group. [ 19 ] Pharmacokinetic studies of SZ in humans have demonstrated a longer half-life (SZ 14 h; MTZ 8 h) and higher blood levels than MTZ.…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

et al. 2015

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Aim:The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.Materials and Methods:Seventy subjects with probing depth (PD) ≥5 mm were selected. Thirty-five subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index, gingival index, clinical attachment level (CAL), and PD at baseline; 1 month, 3 months, and 6 months interval. Furthermore, microbial analysis using polymerase chain reaction was done to estimate the number of sites harboring periodontopathogens.Results:Sixty four subjects were evaluated up to 6 months. At 6 months, the Group 2 resulted in greater mean reduction (4.10 mm) in PD as compared to Group 1 (1.49 mm), and also a greater mean CAL gain (4.20 mm) in Group 2 as compared to Group 1 (1.13 mm). These subjects also showed a significant reduction in the number of sites harboring periodontopathogens.Conclusion:The use of 3% SZ gel, when used as an adjunct to nonsurgical periodontal therapy in subjects with periodontitis, achieved better results than initial periodontal treatment alone.

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Comparative studies on the amoebicidal activity of known 5-nitroimidazole derivatives and CG 10213-Go in golden hamsters, Mesocricetus auratus, infected in the liver or caecum or both with trophozoites of Entamoeba histolytica

Cited by 17 publications

References 5 publications

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

Randomized, Single-Blind, Placebo-Controlled Multicenter Trial to Compare the Efficacy and Safety of Metronidazole and Satranidazole in Patients With Amebic Liver Abscess

Nouveau modèle expérimental d’amibiase cæcale chez le rat

Clinical and microbiological efficacy of 3% satranidazole gel as a local drug delivery system in the treatment of chronic periodontitis: A randomized, controlled clinical trial

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