Malaria adalah suatu penyakit yang disebabkan oleh parasit yang termasuk dalam anggota spesies dari genus Plasmodium. Plasmodium knowlesi adalah parasit malaria yang ditemukan pada kera ekor-panjang dan ditemukan pertama kali pada tahun 1930 pada spesimen Macaca fascicularis dari Singapura. Pada tahun 2004 dilaporkan terjadi infeksi P. knowlesi pada manusia di Sarawak, Borneo Malaysia dan penemuan ini menjadikan P. knowlesi sebagai spesies parasit malaria kelima yang menginfeksi manusia. Plasmodium knowlesi dapat melangsungkan siklus eritrositiknya dalam waktu 24 jam sehingga dapat menyebabkan progresifitas infeksi yang lebih tinggi dibandingkan plasmodium lainnya. Transmisi P. knowlesi yang beralih menginfeksi manusia melibatkan beberapa faktor, baik secara demografis, lingkungan ataupun kebiasaan individu.

The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of 0.3 μg/mL (5.967 x 10-7 M).

Artonin E was isolated from the root bark of A. rigida. The isolated compound was then esterified using a known procedure by the addition of acetic anhydride with pyridine catalyst. The structure of the synthesized compound was carefully determined by physical and spectroscopic techniques and compared to the data in the literature. The anticancer activity test against murine leukemia cancer cells P-388 showed that the ester compound has good activity with an IC50 of 2.79 μg/mL and much better stability during storage compared to Artonin E itself.

A xanthone derivative, artonin O(1),has successfully been isolated from root wood of Artocarpus rigida grown in Lampung, Indonesia. The structure of this compound has been carefully determined by some spectroscopy techniques and based on physical data. The antibacterial activity test on this compound towards Bacillus subtilis, showed that it has medium activity.

Objective: The aim of this study was to assess the antiplasmodial and cytotoxic activities and to evaluate the selectivity indices of acetone, ethanol and aqueous extracts of Peronema canescens leaves. Methods:Antiplasmodial activity was measured in vitro against Plasmodium falciparum strains D10 and FCR3 by 72 h incubation at 37 °C in a candle jar. Parasitaemia was calculated by counting the parasite numbers in thin smears. In vitro cytotoxicity was assayed in Vero cells using 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and reading the absorbency at 595 nm with an ELISA reader. The assessed parameters included: 50% inhibitory concentration (IC50) of antiplasmodial activity, IC50Results: The IC of cytotoxic activity and the selectivity index of the Peronema canescens leaf extract. 50 values for the acetone, ethanol and aqueous extracts were 26.33±1.65, 37.96±8.17 and 12.26±1.05 μg/ml, respectively, against the Plasmodium falciparum D10 strain and 51.14±8.65, 70.22±14.13 and 34.85±6.04 μg/ml, respectively, against the FCR3 strain. For Vero cells, the IC50 Conclusion:The aqueous extract of Peronema canescens leaves had the highest in vitro antiplasmodial activity and the best selectivity index. values for the acetone, ethanol and aqueous extracts were 23.37±5.63, 629.46±24.85 and 634.00±144.82 μg/ml, respectively. The selectivity indices of these extracts were 0.89, 16.46 and 51.70, respectively, for the D10 strain and 0.46, 8.90 and 18.00, respectively, for the FCR3 strain.

From the root bark of Artocarpus dadah grown in Lampung, Indonesia have successfully been isolated two flavan derivatives, afzelecin-3-O-α-L-ramnoside and chatecin. The structure of both compounds were determined based on physical properties and UV-VIS, IR and NMR spectroscopies.

ABSTRACT Background: Toxoplasmosis is an infection caused by protozoan Toxoplasma gondii which has complex life cycle in warm-blooded organisms, including human as intermediate hosts and cats as definitive hosts. This infection transmits through orofecal, blood transfusion, organ transplantation from infected donors and vertically from mothers to the fetus per placenta. High rate of seroprevalency among pregnant women shows the importance of educating pregnant women about toxoplasmosis and the preventive behaviours. This study purpose is to determine the differences of knowledge levels and behaviours about toxoplasmosis between pregnant women in Kemiling Primary Health Care and obstetric clinic in Bandar Lampung. Methods: This is a descriptive-analytic study with cross-sectional approachment using questionairs as the instrument of the study. The number of subjects in this study is 106 pregnant women. Statistic analysis that is used is Chi Square Test. Results: The good knowledge levels and behaviours in Kemiling Primary Health Care is 22,6% while in the obstetric clinic it reached 75,5%. As the result of bivariate analysis, the p value is 0,001. Conclusions: In conclusion, there is a significant difference of knowledge levels and behaviours about toxoplasmosis between pregnant women in Kemiling Primary Health Care and obstetric clinic in Bandar Lampung. Keywords : behaviour, knowledge, pregnant women, toxoplasmosis, Toxoplasma gondii   ABSTRAK Latar Belakang: Toksoplasmosis adalah penyakit infeksi yang disebabkan oleh protozoa Toxoplasma gondii yang memiliki siklus hidup kompleks pada organisme berdarah panas, termasuk manusia sebagai hospes perantara dan kucing sebagai hospes definitif. Infeksi ini menular secara orofekal, transfusi darah, transplantasi organ dari pendonor yang positif terinfeksi atau juga terjadi pada saat kehamilan dari ibu ke janin melalui plasenta. Tingginya tingkat prevalensi toksoplasmosis pada ibu hamil menunjukkan pentingnya edukasi bagi ibu hamil untuk meningkatkan pengetahuannya tentang toksoplasmosis dan perilaku pencegahannya. Tujuan dari penelitian ini adalah mengetahui perbedaan tingkat pengetahuan dan sikap ibu hamil tentang toksoplasmosis di Puskesmas Kemiling dan klinik spesialis di Bandar Lampung. Metode: Penelitian ini bersifat deskriptif analitik dengan pendekatan cross-sectional dengan menggunakan kuesioner sebagai instrument penelitian. Jumlah subjek pada penelitian ini yaitu sejumlah 106 ibu hamil. Analisis statistik yang digunakan adalah Uji Chi Square. Hasil: Tingkat pengetahuan dan sikap yang baik sebesar 22,6% di Puskesmas Kemiling dan sebesar 75,5% di klinik spesialis kandungan di Bandar Lampung. Hasil analisis bivariat didapatkan p value sebesar 0,001. Kesimpulan: Terdapat perbedaan tingkat pengetahuan dan sikap ibu hamil tentang toksoplasmosis di Puskesmas Kemiling dan klinik spesialis kandungan di Bandar Lampung. Kata Kunci : ibu hamil, pengetahuan, sikap, toksoplasmosis, Toxoplasma gondii

Abstrak. Petani memiliki risiko terinfeksi Soil-Transmitted Helminth (STH) akibat sering berkontak langsung dengan tanah yang terkontaminasi oleh telur STH. Tingginya risiko terinfeksi STH pada petani berhubungan dengan perilaku personal hygiene dan pemakaian alat pelindung diri saat bekerja. Tujuan dilakukan penelitian untuk mengetahui angka kejadian infeksi STH dan faktor yang mempengaruhinya. Penelitian dilaksanakan di Kelurahan Pinang Jaya, Lampung. Populasi pada penelitian ini  adalah 63 petani dan sampel dipilih sebanyak 55 petani dengan teknik purposive sampling. Data diperoleh dengan pemeriksaan feses, pengisian kuesioner, dan observasi. Data dianalisis dengan menggunakan α =5%.  Hasil penelitian didapatkan prevalensi STH pada petani sebanyak 40% dengan jenis telur cacing  A.lumbricoides (22,7%), cacing tambang (59,1%), dan  terinfeksi keduanya (18,2%). Sebagian besar personal hygiene petani baik (63,6%) dan sebagian besar petani tidak lengkap menggunakan APD (69,1%). Hasil analisis menunjukkan bahwa personal hygiene dan penggunaan APD berhubungan terhadap kejadian STH (pα). Diperlukan edukasi kepada petani untuk dapat meningkatkan personal hygiene dan menggunakan alas kaki untuk melindungi diri dari risiko STH. Keyword:  infeksi Soil Transmited Helminth, petani Abstract. Farmers have the risk of being infected with STH due to frequent direct contact with the soil which contaminated by STH eggs. The high risk of STH infection among farmers is related to personal hygiene behavior and the use of personal protective equipment while working. The purpose of this study is to determine the prevalence of STH and the factors that influence it. The study was conducted in Pinang Jaya Village, Lampung. The population in this study was 63 farmers and a sample of 55 farmers was selected by purposive sampling technique. Data obtained by stool examination, filling out questionnaires, and observing. Data were analyzed using α = 5%. The results showed that the prevalence of STH among farmers was 40% with A. lumbricoides eggs (22.7%), hookworms (59.1%), and both infected (18.2%). Most of the farmers' personal hygiene was good (63.6%) and most farmers did not completely use PPE (69.1%). The results of the analysis showed that personal hygiene and the use of PPE were related to the incidence of STH (p α. Education is needed for farmers to improve personal hygiene and use footwear to protect themselves from the risks of STH. Keywords: Soil Transmited Helminth  infection, personal hygiene, farmers