Artonin O, a Xanthone Compound from Root Wood of Artocarpus Rigida

Abstract

A xanthone derivative, artonin O(1),has successfully been isolated from root wood of Artocarpus rigida grown in Lampung, Indonesia. The structure of this compound has been carefully determined by some spectroscopy techniques and based on physical data. The antibacterial activity test on this compound towards Bacillus subtilis, showed that it has medium activity.

Isolation of Artonin E from the root bark of Artocarpus rigida, synthesis of Artonin E acetate and evaluation of anticancer activity

“…Some flavonoid compounds have been isolated from some species of Artocarpus and some of the compounds isolated have shown interesting biological activities [1][2][3][4][5][6]; one of the compounds is artonin E. Artonin E is a flavonoid compound which potential anticancer and antimalaria activity [7,8] and can easily be isolated from various Artocarpus plant such as A. communis, A. rotunda, A. altilis, A. elasticus and A. rigida [3,4,7,[9][10][11][12].…”

Artocarmins G–M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities

“…The 1 H NMR data (Table 1) showed signals for a set of meta aromatic protons [δ H 6.24 (d, J = 2.0 Hz) and 6.33 (d, J = 2.0 Hz)], an isolated aromatic proton [δ H 6.87 (s)], two prenyl groups [δ H 5.08 (t, J = 7.1 Hz), 5.28 (t, J = 7.0 Hz), 3.08 (d, J = 7.1 Hz), 3.41 (d, J = 7.0 Hz), 1.37 (s), 1.55 (s), 1.66 (s), and 1.77 (s)], a methoxy group (δ H 3.58), and a distinctive signal of a hydrogen-bonded hydroxy group (δ H 13.09). The 13 C NMR data (Table 1) exhibited resonances for a ketocarbonyl (δ C 182.0), 12 1). Except for the presence of a methoxy group in 2, these 1 H and 13 C NMR data closely resembled those of KB-2.…”

“…In Vietnam, A. rigida , known as “Mit nai”, is used as a traditional medicine to aid in wound healing . Phytochemical studies on its chemical constituents have led to the identification of many types of secondary metabolites including stilbenes, xanthones, and prenylated flavonoids, which have been found to have cytotoxic, antiplasmodial, anti-inflammatory, and antibacterial activities. − …”

Natural Prenylflavones from the Stem Bark of Artocarpus altilis: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway

“…Artonin E, also known as 5′-hydroxymorusin, possesses a flavonoid skeleton linked to a lipophilic prenyl side chain. Initially detected in the bark of AA, this molecule has been widely explored for its varied pharmacological activities, encompassing antibacterial, anticancer, antiestrogenic, anti-FAT10, antimalarial, antinephritis, antioxidant, and antiplasmodial activities . The anticancer effects of Artonin E have been explored across diverse cancer cell types, including breast (MCF-7, MDA-MB-231), , colon (LoVo, HCT116), , gastric cancers (AGS), leukemia (P-388), lung (H460, H23, H292, A549), , and ovarian (SKOV3, 1A9). , These studies highlight the potential of artonin E in inducing apoptosis, anoikis, and cell-cycle arrest and inhibiting proliferation, invasion, migration, and overcoming resistance to the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). – The underlying mechanisms involve activation and suppression of proapoptotic and antiapoptotic proteins, respectively.…”