The concept of novel drug delivery systems aims at achieving systematically improved therapeutic success for drugs including those that have limited use because of toxicity, uneven distribution pattern, stability and formulation of difficulties. The paper reveals the potential uses of novel hybrids of oleic acid-g-chitosan and montmorillonite (OA-g-CS/MMT) in controlled drug delivery applications. A calcium channel blocker is a chemical that disrupts the movement of calcium (Ca 2+ ) through calcium channels. The calcium channel blocker used for the present investigation is diltiazem hydrochloride, which forms a class three antianginal drug, and a class IV antiarrhythmic. The drug-loaded novel composites have been prepared by solvent casting and freeze drying of the grafted polymer solution. Drug release was monitored by changing time, percentage of drug loading and pH of the medium. It was observed that the release was much more pronounced in the basic medium than in the acidic medium. The maximum release of drug from OA-g-CS/MMT in both gastric and intestinal fluids was observed within a time period of 12 h.
The superior antimicrobial properties of nanosilver (AgNP) led to its applications in healthcare and hygiene products. Herein, we report an efficient and simple green chemistry approach for the synthesis of AgNP by in‐situ reduction and capping by an eco‐friendly carbohydrate polymer, alginate dialdehyde (ADA). The UV‐Vis absorption maxima of the ADA‐capped silver nanoparticles (ADA‐AgNPs) showed a surface plasmon resonance peak at 411 nm, a peak characteristic to silver nanoparticles, within 30 min of the onset of the reaction. They were spherical, had an average diameter of 18.68±2.5 nm and had face‐centered cubic structure. Its storage stability was tested up to 90 days by monitoring its zeta potential and it was found to be stable around −35.1±1.71 mV. ADA‐AgNPs exhibited good antimicrobial properties against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) and excellent antibiofilm activity against S. aureus at its minimum inhibitory concentration of 34 μg/mL. ADA‐AgNPs showed good anticancer action against HCT‐116 cells too.
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