Injectable self-crosslinking hydrogels for meniscal repair: A study with oxidized alginate and gelatin

Resmi, R.; Parvathy, J.; John, Annie; Joseph, Roy

doi:10.1016/j.carbpol.2020.115902

Cited by 88 publications

(58 citation statements)

References 62 publications

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“…Usually, physical cross-linking such as hydrogen bonding, and hydrophobic and electrostatic interactions are preferred routes for gelation. Furthermore, chemical, enzymatic and photochemical routes are also readily used, though there are concerns of toxicity, apoptosis and prolonged irradiation [ 9 , 10 ]. Injectable hydrogels are being used for a plethora of biomedical applications ranging from delivery vehicle for payloads such as genes, nutrients, drugs, etc., for the treatment of a multitude of diseases and cancers to tissue regeneration such as skin, muscles, bones and cartilage [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

et al. 2020

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In this study we report the preparation of novel multicomponent hydrogels as potential biomaterials for injectable hydrogels comprised of alginate, casein and bacterial cellulose impregnated with iron nanoparticles (BCF). These hydrogels demonstrated amide cross-linking of alginate–casein, ionic cross-linking of alginate and supramolecular interaction due to incorporation of BCF. Incorporation of BCF into the hydrogels based on natural biopolymers was done to reinforce the hydrogels and impart magnetic properties critical for targeted drug delivery. This study aimed to improve overall properties of alginate/casein hydrogels by varying the BCF loading. The physico-chemical properties of gels were characterized via FTIR, XRD, DSC, TGA, VSM and mechanical compression. In addition, swelling, drug release, antibacterial activity and cytotoxicity studies were also conducted on these hydrogels. The results indicated that incorporation of BCF in alginate/casein hydrogels led to mechanically stronger gels with magnetic properties, increased porosity and hence increased swelling. A porous structure, which is essential for migration of cells and biomolecule transportation, was confirmed from microscopic analysis. The porous internal structure promoted cell viability, which was confirmed through MTT assay of fibroblasts. Moreover, a hydrogel can be useful for the delivery of essential drugs or biomolecules in a sustained manner for longer durations. These hydrogels are porous, cell viable and possess mechanical properties that match closely to the native tissue. Collectively, these hybrid alginate–casein hydrogels laden with BCF can be fabricated by a facile approach for potential wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

et al. 2020

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“…All these effects were rationalized by invoking the formation of more reactive hydroxyethyl radicals during the oxidation reaction [34]. Concerning spectroscopic characterization, the Raman spectrum in Figure 2 shows the characteristic peaks of NaAlg [35,36] where symmetrical and asymmetrical stretching vibrations of -COO − at 1420 and 1600 cm −1 occurred together with a C-O stretch at 1330 cm −1 and a C-O-C stretch at 1100 cm −1 .…”

Section: Synthesis Of Algox and Algox-da And Raman Spectroscopy Identificationmentioning

confidence: 96%

Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

et al. 2021

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Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.

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“…second network improved mechanical properties [81] PVA/P(AAm-co-SA) -second network improved mechanical and pH-responsive properties [82] PVA/AG -AG boost self-healing and improved mechanical strength [83] LBG/Gg pH-driven shape memory ultrafast self-healing with high mechanical properties [84] PVA/CST -CST improved machinal properties [85] HA-DP Corsslinked PAAm strain sensors mussel-inspired flexible, wearable, and self-adhesive [86] Other types of borax-based hydrogels oxidized-alginate gelatin injectable in situ forming biodegradable scaffolds for cartilage regeneration and/or treatment of meniscal injuries gelatin create dynamic imine crosslinking with oxidized alginate [87][88][89] PVA/PSA/PNIPAAm thermoresponsive touch sensors PSA/PNIPAAm improved mechanical properties; induce thermo-sensitivity Although the history for the synthesis of polyol/B hydrogels, such as PVA/B [33,40] and galactomannan/B [41] hydrogels, is turned back to the 20 th century, more detailed studies have been performed on the characteristics of these hydrogels in recent years. The stability evaluation of scleroglucan (Sclg)/B hydrogels in aqueous media showed that in high acidic and high alkaline media the stability is reduced significantly.…”

Section: Neat Polyol/borax Hydrogelsmentioning

confidence: 99%

“…The oxidized alginate/gelatin/B system was also used as an injectable hydrogel for the treatment of meniscal injuries. [89] Stretchable, thermoresponsive and self-healing conductive hydrogels composed of PVA/PSA/PNIPAAm/B (PSA = poly sodium acrylate) were produced for application as wearable multimodal touch sensors. [90] Increasing the PSA content reduced transparency of the hydrogel due to the aggregation and heterogeneous distribution of PSA in the hydrogel matrix which leads to higher light scattering, refraction, or reflection.…”

Section: Other Types Of Borax-based Hydrogelsmentioning

confidence: 99%

“…The hydrogel could integrate the cartilage tissue with a burst pressure of 70 mm Hg and improved adhesivity which was attributed to the imine formation between free aldehyde groups of oxidized alginate with the available amino groups of collagen in cartilage. The oxidized alginate/gelatin/B system was also used as an injectable hydrogel for the treatment of meniscal injuries …”

Section: Other Types Of Borax‐based Hydrogelsmentioning

confidence: 99%

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Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

Seidi

Jin

Han

et al. 2020

The Chemical Record

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Self-healing polyol/borax hydrogels have found great applications in various areas; especially in sensors, flexible electronics and biomedical fields. In this review, fabrication and characteristics of various types of borax-based hydrogels are discussed. Mechanical properties and self-healing behaviors of these hydrogels are strongly affected by the types of polyol, ratio of polyol:borax, and concentration of each component. Incorporation of highly polar nanofillers (such as cellulose nanofibers) into hydrogels and fabrication of double-network structures have been employed as the promising strategies for improving the mechanical properties. Other additives have also been examined to generate nanocomposite hydrogels for a wide variety of uses; e. g. polyphenols for developing adhesives, conducting polymers, and hybrid structures based on carbon nanotubes and graphenes for electroconductivity, Ag and ZnO nanoparticles for antibacterial property, and quantum dots for fluorescence.

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Injectable self-crosslinking hydrogels for meniscal repair: A study with oxidized alginate and gelatin

Cited by 88 publications

References 62 publications

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

Self‐healing Polyol/Borax Hydrogels: Fabrications, Properties and Applications

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