A novel composite matrix based on polymeric micelle and hydrogel as a drug carrier for the controlled release of dual drugs

Anirudhan, T.S.; Parvathy, J.; Nair, A. Sreekumaran

doi:10.1016/j.carbpol.2015.10.019

Cited by 56 publications

(27 citation statements)

References 35 publications

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“…Combined delivery of anticancer drugs with different mechanisms of action allows overcoming undesirable toxicity and other side effects and to circumvent multidrug resistance [41]. Many DDDS reported in the literature are based on hydrogel/polymeric micelle composites [41,42,43,44]. These dual systems have also been used for controlled delivery in hard tissue engineering [45,46], where different drugs or a combination of drugs and cells or growth factors were used.…”

Section: Resultsmentioning

confidence: 99%

Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

et al. 2019

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A (model) composite system for drug delivery was developed based on a thermoresponsive hydrogel loaded with microparticles. We used Pluronic F127 hydrogel as the continuous phase and alginate microparticles as the dispersed phase of this composite system. It is well known that Pluronic F127 forms a gel when added to water in an appropriate concentration and in a certain temperature range. Pluronic F127 hydrogel may be loaded with drug and injected, in its sol state, to act as a drug delivery system in physiological environment. A rheological characterization allowed the most appropriate concentration of Pluronic F127 (15.5 wt%) and appropriate alginate microparticles contents (5 and 10 wt%) to be determined. Methylene blue (MB) was used as model drug to perform drug release studies in MB loaded Pluronic hydrogel and in MB loaded alginate microparticles/Pluronic hydrogel composite system. The latter showed a significantly slower MB release than the former (10 times), suggesting its potential in the development of dual cargo release systems either for drug delivery or tissue engineering.

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Section: Resultsmentioning

confidence: 99%

Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

et al. 2019

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“…However the controlled dual administration of multiple drugs, each with their own distinct physical and chemical properties, is challenging. A hydrogel/ micelle composite prepared from PEG and poly(vinyl alcohol) (PVA) with embedded tramadol, and oleic acid-g-chitosan copolymer micelles loaded with the antibiotic cefixime was developed as a dual-drug release carrier 38 allowing efficient release of two very different drugs. A drug carrier prepared from a CS/PVA hydrogel encapsulating aspirin and poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly(L-glutamic acid) micelles entrapping DOX showed independent release behaviour of each drug.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Qiu

Yang

et al. 2018

J. Mater. Chem. B

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“…Thus, the employment of secondary vehicles is able to overcome issues of hydrophobic drug loaded in the gel and improve the delivery of hydrophobic drug into aqueous medium. 109,110 One promising strategy is the delivery of hydrophobic drug in the form of nanoparticles embedded in hyaluronic acid hydrogels 110 or from hybrid beads of alginate, double hydroxides and magnetic graphite nanoparticles. 111 The drug release behavior and the porosity of the ferrogels can be affected by turning on and off the magnetic field.…”

Section: Drug Deliverymentioning

confidence: 99%

Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications

Frachini¹,

Petri²

2019

J. Braz. Chem. Soc.

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Hydrogels are hydrophilic three-dimensional networks able to hold large amount of water and hydrophilic molecules. Magneto-responsive hydrogels comprise of magnetic nanoparticles dispersed in polymeric networks that can be manipulated under external magnetic field. This review aims at (i) giving a brief overview on the evolution of hydrogels until the design and development of magnetic hydrogels; (ii) describing the types of hydrogels and the basic concepts about superparamagnetic iron oxide nanoparticles, as well as the preparation and characterization of magneto-responsive hydrogels; (iii) displaying the relevant applications of magneto-responsive hydrogels for drug delivery, regenerative medicine of tissues, cancer therapy and environmental issues and (iv) highlighting the challenges and future trends of magneto-responsive hydrogels for 3D and 4D printing.

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A novel composite matrix based on polymeric micelle and hydrogel as a drug carrier for the controlled release of dual drugs

Cited by 56 publications

References 35 publications

Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

Biodegradable pH-responsive hydrogels for controlled dual-drug release

Magneto-Responsive Hydrogels: Preparation, Characterization, Biotechnological and Environmental Applications

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