Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

Cidade, M. T.; Ramos, David J.; Santos, José Lúıs; Carrêlo, Henrique; Calero, Nuria; Borges, João Paulo

doi:10.3390/ma12071083

Cited by 46 publications

(40 citation statements)

References 48 publications

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“…An example of in situ gelation is the use of thermosensitive hydrogels as matrices capable of sustaining the particles [ 11 , 16 , 17 ]. Before injection, at a temperature in which the hydrogel is in the sol state, the particles can be added, forming a suspension with the particles homogeneously distributed.…”

Section: Microparticles In Hydrogel Systemsmentioning

confidence: 99%

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Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery

Carrêlo

Soares

Borges

et al. 2021

Gels

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Engineering drug delivery systems (DDS) aim to release bioactive cargo to a specific site within the human body safely and efficiently. Hydrogels have been used as delivery matrices in different studies due to their biocompatibility, biodegradability, and versatility in biomedical purposes. Microparticles have also been used as drug delivery systems for similar reasons. The combination of microparticles and hydrogels in a composite system has been the topic of many research works. These composite systems can be injected in loco as DDS. The hydrogel will serve as a barrier to protect the particles and retard the release of any bioactive cargo within the particles. Additionally, these systems allow different release profiles, where different loads can be released sequentially, thus allowing a synergistic treatment. The reported advantages from several studies of these systems can be of great use in biomedicine for the development of more effective DDS. This review will focus on in situ injectable microparticles in hydrogel composite DDS for biomedical purposes, where a compilation of different studies will be analysed and reported herein.

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Section: Microparticles In Hydrogel Systemsmentioning

confidence: 99%

“…The combination of microparticles and hydrogels as a composite system for bioactive cargo delivery has been the focus of different studies ( Figure 1 ) [ 10 , 11 ]. This system will have advantages when compared to hydrogels or microparticles alone.…”

Section: Introductionmentioning

confidence: 99%

Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery

Carrêlo

Soares

Borges

et al. 2021

Gels

Self Cite

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“…FTIR analysis performed in the region of 4000 to 400 cm -1 by the Fourier transformer spectroscopy technique (Perkin-Elmer spectrophotometer, Germany; model 2000 FTIR). Drug (FLZ) and polymer compatibility study was done by taking FLZ, and polymers; pluronic F127, sodium alginate alone and in combination with potassium bromide spectra were interpreted for possible physicochemical interactions [15].…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Fatima¹

2021

jrp

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The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na + activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole (0.3%w/v), Pluronic F127(1%w/v), sodium alginate (0.5%w/v), sodium chloride (0.9w/v), benzalkonium Chloride (0.01%w/v) and acetate buffer pH 4 up to 100%w/v), showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated (99.89±0.78 %) with 100% in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.87±0.65 mm; 20.76±0.23 mm in comparison to marketed fluconazole conventional gel formulation (15.98±0.98 mm; 18.98±0.76 mm) for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

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“…It is worth noting that we are still a great distance from organ printing. Even though recent deposition and manufacturing systems permit us to develop structures similar to tissue in their composition, the progression of entirely functioning tissue is a much more significant step [ 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 ].…”

Section: Limitations Advantages and Future Prospects Of Alg 3d Prmentioning

confidence: 99%

Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

et al. 2020

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Three-dimensional (3D) bioprinting is an appealing and revolutionary manufacturing approach for the accurate placement of biologics, such as living cells and extracellular matrix (ECM) components, in the form of a 3D hierarchical structure to fabricate synthetic multicellular tissues. Many synthetic and natural polymers are applied as cell printing bioinks. One of them, alginate (Alg), is an inexpensive biomaterial that is among the most examined hydrogel materials intended for vascular, cartilage, and bone tissue printing. It has also been studied pertaining to the liver, kidney, and skin, due to its excellent cell response and flexible gelation preparation through divalent ions including calcium. Nevertheless, Alg hydrogels possess certain negative aspects, including weak mechanical characteristics, poor printability, poor structural stability, and poor cell attachment, which may restrict its usage along with the 3D printing approach to prepare artificial tissue. In this review paper, we prepare the accessible materials to be able to encourage and boost new Alg-based bioink formulations with superior characteristics for upcoming purposes in drug delivery systems. Moreover, the major outcomes are discussed, and the outstanding concerns regarding this area and the scope for upcoming examination are outlined.

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Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications

Cited by 46 publications

References 48 publications

Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery

Injectable Composite Systems Based on Microparticles in Hydrogels for Bioactive Cargo Controlled Delivery

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Recent Trends in Three-Dimensional Bioinks Based on Alginate for Biomedical Applications

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