Novel semi-IPN based on crosslinked carboxymethyl starch and clay for the in vitro release of theophylline

Anirudhan, T.S.; Parvathy, J.

doi:10.1016/j.ijbiomac.2014.03.041

Cited by 30 publications

(14 citation statements)

References 27 publications

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“…Non-crosslinked CMS-based films are soluble in cold water [ 4 , 5 ]. Applying crosslinking agent, such as: sodium trimetaphosphate [ 6 ], sodium hexametaphosphate [ 7 ], dichloroacetic acid [ 8 ], or multifunctional carboxylic acids [ 9 , 10 ] allowed to obtained hydrogel material with various swelling capacity. The mechanical strength of CMS-based films could be improved by introducing clay nanoparticles [ 7 , 10 ] or by blending CMS with other polymer, e.g., starch [ 11 ] or zein [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Applying crosslinking agent, such as: sodium trimetaphosphate [ 6 ], sodium hexametaphosphate [ 7 ], dichloroacetic acid [ 8 ], or multifunctional carboxylic acids [ 9 , 10 ] allowed to obtained hydrogel material with various swelling capacity. The mechanical strength of CMS-based films could be improved by introducing clay nanoparticles [ 7 , 10 ] or by blending CMS with other polymer, e.g., starch [ 11 ] or zein [ 12 ]. Blending CMS with CMC would allow to impart new functional properties, e.g., biodegradable material with modified hydrophilicity, which could be beneficial for agricultural purposes or desirable for active food packaging [ 13 ], edible coating [ 14 , 15 ], as well as in pharmacy (drug carrier) [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

et al. 2020

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The carboxymethylated derivatives of starch (CMS) and cellulose (CMC) were used for film preparation. The infrared spectroscopy revealed that crosslinking via ester bridges with citric acid occurred between the two polysaccharide derivatives. The effect of polysaccharide derivatives ratio on physicochemical properties of prepared films was evaluated. Generally, the values of tested parameters (moisture absorption, surface roughness, and mechanical and thermal properties) were between the values noted for neat CMS or CMC-based films. However, the physicochemical properties of the system with equal CMS/CMC weight ratio diverged from this trend, i.e., the highest tensile strength, the highest Young’s modulus (ca. 3.4 MPa and ca. 4.9 MPa, respectively), with simultaneously the lowest moisture absorption (18.5% after 72 h) have been noted. Such systems could potentially find application in agriculture or pharmacy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

et al. 2020

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“…Some researchers have used SEM to detect the phase separations in order to demonstrate the formation of semi‐IPN. In addition, several scientists not only using SEM, but also have used FTIR spectroscopy to prove semi‐IPN structures by analyzing the formation of crosslinked and linear polymers by multi‐functional monomers and bi‐functional monomers . Herein, TGAP and DDS acting as multi‐functional monomers were used to form the epoxy crosslinked structure.…”

Section: Resultsmentioning

confidence: 99%

Epoxy resins toughened with in situ azide–alkyne polymerized polysulfones

Ying

Yang

Moon

et al. 2017

J of Applied Polymer Sci

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To simultaneously improve the fracture toughness and heat resistance of a cured toughened epoxy resin along with a reduction in its viscosity during the mixing process, two novel polysulfone‐type polymers are synthesized via azide–alkyne polymerization for use as toughening agents. The epoxy resin toughened with these polymers by in situ azide–alkyne polymerization during the cure process, which shows excellent processibility and based on the significantly lower viscosity (61 and 62 cP) during epoxy mixing process than that of commonly commercial polyethersulfone (PES, 127,612 cP). The novel polysulfone‐type polymer toughened epoxy resin showed the advantage in excellent fracture toughness than the PES toughened epoxy. In addition, the glass transition temperature of the novel polysulfone‐type polymer toughened epoxy resin is similar to that of the neat one (∼230 °C) and does not decrease, which implies excellent heat resistance of the toughened epoxy. These phenomena can be attributed to the formation of semi‐interpenetrating polymer networks comprising the epoxy network and the linear polysulfone‐type polymers. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45790.

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“…Fig. 2 shows the schematic representation of the Semi-IPN drug delivery system (Anirudhan & Parvathy, 2014).…”

Section: Carboxymethyl Starch Based Matrices As Effective Drug Carriersmentioning

confidence: 99%

Carboxymethyl starch as a polymeric plant based excipient in drug delivery

Anirudhan

Parvathy

2014

Plant Sci. Today

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Polysaccharides extracted and isolated from plant products serve as potential candidates in pharmaceutics mainly drug delivery, owing to its biodegradability, bioavailability and non-toxic character. Hydrogels, three-dimensional hydrophilic polymeric networks, exhibit dramatic changes in their swelling behaviour, network structure, and mechanical strength in response to different stimuli to the body. A wide variety of polysaccharides (chitosan, alginate, cellulose, starch, etc) and their derivatives have been used to synthesize hydrogels that tend to swell in water or biological fluids. Such systems have numerous biomedical applications including: drug delivery, wound dressing, and tissue engineering. However, single-network hydrogels have weak mechanical properties and slow response at swelling. To enhance the mechanical strength and swelling/deswelling response of hydrogels, multicomponent networks as interpenetrating polymer networks have also been reported and recently have gained much importance in research on different biomedical applications. The present review focuses on the application of carboxymethyl starch as a pharmaceutical excipient where the effect of crosslinking modification and the formation of Semi Interpenetrating Polymer Network with montmorillonite clay mineral have been investigated.

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Novel semi-IPN based on crosslinked carboxymethyl starch and clay for the in vitro release of theophylline

Cited by 30 publications

References 27 publications

Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

Hydrophilic Films Based on Carboxymethylated Derivatives of Starch and Cellulose

Epoxy resins toughened with in situ azide–alkyne polymerized polysulfones

Carboxymethyl starch as a polymeric plant based excipient in drug delivery

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