Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma

Anirudhan, T.S.; Nair, A. Sreekumaran; Parvathy, J.

doi:10.1016/j.ejpb.2016.09.010

Cited by 36 publications

(17 citation statements)

References 40 publications

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“…The drug is then re-loaded in the polymer by soaking and interacting with the memory sites. This process can lead to a higher drug loading and a slower release profile [81], and it was successfully applied to therapeutic CLs and IOLs [82][83][84][85][86][87][88]. The use of miscible combinations of drugs and monomers is generally preferable over non-miscible ones in order to avoid the use of solvents, since their presence could prevent the orientation of monomers around the drug molecules and result in a less effective imprinting [89].…”

Section: Molecular Imprintingmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

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Section: Molecular Imprintingmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

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“…Contact lenses comprised of timolol maleate imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide (CmCS-gHEMA-g-pAAm) embedded onto a polyHEMA matrix (pHEMA) were formed [62]. They were intended for reloading, while most of previously developed imprinted lenses were disposable.…”

Section: Modern Ophthalmic Drug Release Systemsmentioning

confidence: 99%

“…Cumulative percent release of timolol maleate from timolol-loaded contact lenses after first, second, third, and fourth cycle of drug loading [62]. …”

Section: Figurementioning

confidence: 99%

Targeted Drug Delivery Systems for the Treatment of Glaucoma: Most Advanced Systems Review

Olga

2019

Polymers

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Each year, new glaucoma drug delivery systems are developed. Due to the chronic nature of the disease, it requires the inconvenient daily administration of medications. As a result of their elution from the eye surface and penetration to the bloodstream through undesired permeation routes, the bioavailability of active compounds is low, and systemic side effects occur. Despite numerous publications on glaucoma drug carriers of controlled drug release kinetics, only part of them consider drug permeation routes and, thus, carriers’ location, as an important factor affecting drug delivery. In this paper, we try to demonstrate the importance of the delivery proximal to glaucoma drug targets. The targeted delivery can significantly improve drug bioavailability, reduce side effects, and increase patients’ compliance compared to both commercial and scientifically developed formulations that can spread over the eye surface or stay in contact with conjunctival sac. We present a selection of glaucoma drug carriers intended to be placed on cornea or injected into the aqueous humor and that have been made by advanced materials using hi-tech forming methods, allowing for effective and convenient sustained antiglaucoma drug delivery.

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“…Collagen/chitosan gel composite supplemented with a cell-penetrating peptide (oligo-arginine R8) with an antibacterial activity [112] Silver nanoparticles encapsulation into chitosan-based membranes without altering the wound healing ability [ Timolol maleate imprinted copolymer of carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-polyacrylamide incorporated on a pHEMA matrix for glaucoma [122] N-Trimethyl Chitosan Nanoparticles loaded with flurbiprofen-hydroxyl propyl-β-cyclodextrin inclusion complex [123] Layer-by-layer deposition of chitosan and alginate was used to control drug release from ophthalmic lens materials [124] Vaccine Inactivated avian influenza H5N1 virus vaccine encapsulated in chitosan nanoparticles in broiler chickens [125] Chitosan coated PLGA microparticles for intranasal vaccine delivery of hepatitis B surface Antigen [126] Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 6 May 2019 doi:10.20944/preprints201905.0066.v1…”

Section: Tissue Engineeringmentioning

confidence: 99%

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

Casadidio

Peregrina

Gigliobianco

et al. 2019

Preprint

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Huge amounts of chitin and chitosans can be found in the biosphere as important constituent of the exoskeleton of many organisms, as well as waste by worldwide seafood companies. Nowadays, politicians, environmentalists, and industrialists encouraged the use of these marine polysaccharides as renewable source, particularly when developed by alternative eco-friendly processes, especially in the production of regular cosmetics. The aim of this review is to outline the physicochemical and biological properties and the different bioextraction methods of chitin and chitosans sources, focusing on enzymatic deproteinization, bacteria fermentation, and enzymatic deacetylation methods. Thanks to their biodegradability, non-toxicity, biocompatibility, and bioactivity, the application of these marine polymers is widely used in the contemporary manufacturing of biomedical and pharmaceutical products. In the end, advanced cosmetic products based on chitin and chitosans are presented, analyzing different therapeutic aspects about skin, hair, nail, and oral care. The innovative formulations described can be considered as excellent solutions regarding problems in the various body anatomical sectors.

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Extended wear therapeutic contact lens fabricated from timolol imprinted carboxymethyl chitosan-g-hydroxy ethyl methacrylate-g-poly acrylamide as a onetime medication for glaucoma

Cited by 36 publications

References 40 publications

Therapeutic Ophthalmic Lenses: A Review

Therapeutic Ophthalmic Lenses: A Review

Targeted Drug Delivery Systems for the Treatment of Glaucoma: Most Advanced Systems Review

Chitin and Chitosans: Characteristics, Eco-Friendly Processes and Applications in Cosmetic Science

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