Novel Thiolated Chitosan-Polyethyleneglycol blend/Montmorillonite composite formulations for the oral delivery of insulin

Anirudhan, T.S.; Parvathy, J.

doi:10.1016/j.bcdf.2018.02.003

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…In the case of anionic MPs, their surfaces have been functionalized with thiol functional groups to exhibit mucoadhesive properties by forming disulfide bonds with thiol groups existing in mucins [102,103,104,105,106,107]. Several studies have confirmed that such chemically-modified MPs show a significantly longer residence time in the target, acting as potential candidates for the sustained oral delivery of specific drugs, such as insulin and losartan [96,108].…”

Section: Challenges Associated With Oral Deliverymentioning

confidence: 99%

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

2019

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Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects. Each delivery method has favorable aspects and limitations, each requiring a specific delivery vehicles design. Among various routes, oral delivery has been recognized as the most attractive method, mainly due to its potential for solid formulations with long shelf life, sustained delivery, ease of administration and intensified immune response. At the same time, a few challenges exist in oral delivery, which have been the main research focus in the field in the past few years. The present work concisely reviews different administration routes as well as the advantages and disadvantages of each method, highlighting why oral delivery is currently the most promising approach. Subsequently, the present work discusses the main obstacles for oral systems and explains the most recent solutions proposed to deal with each issue.

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Section: Challenges Associated With Oral Deliverymentioning

confidence: 99%

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

2019

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“…This is responsible for the activity and exchange reactions with organic compounds. Mnt has a large surface area which shows good cation exchange capacity, adsorption capacity, adhesive, and drug-carrying ability [18,117].…”

Section: Montmorillonite Clay (Mnt)mentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

196

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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“…Consequently, after 8 h, almost 70% of insulin was released at a basic pH of 7.4, which revealed the controlled release of the drug. 86 Tolbutamide (TOL), a significant hypoglycemic drug, was released in a controlled manner loaded with CS/PLGA NPs with the solvent evaporation method. Thermal gravity analysis (TGA) and transmission electron microscope (TEM) proved that not only did this copolymer enhance the bioavailability of the drug, but it decreased TOL dosage.…”

Section: Applications Of Chitosan (Cs) and Its Blend Derivatives In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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Novel Thiolated Chitosan-Polyethyleneglycol blend/Montmorillonite composite formulations for the oral delivery of insulin

Cited by 14 publications

References 20 publications

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Advances in Chitosan-Based Nanoparticles for Drug Delivery

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

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