Цель исследования-оценка и сравнение интенсивности воспалительной реакции при введении материала на основе цинкоксид-эвгенольного цемента в костную и мягкие ткани челюсти. Материал и методы. Эксперимент был проведен на 20 кроликах. Пломбировочный материал на основе цинк-оксидэвгенольного цемента вводили в искусственно созданные дефекты в костной и мягких тканях челюсти кролика. На 14-е и 30-е сутки животных выводили из эксперимента. Изготавливали из фрагментов слизистой оболочки и челюсти гистологические препараты. Результаты. Установлено, что пломбировочный материал на основе цинк-оксид-эвгенольного цемента после введения всегда способствовал возникновению воспалительной реакции в тканях, однако интенсивность воспалительного ответа в мягких тканях была достоверно выше, чем в костной ткани. Заключение. Выведение пломбировочного материала является нежелательным, так как влечет за собой комплекс реакций, направленных на его ликвидацию. Наиболее выраженный воспалительный ответ наблюдается при выведении материала в мягкие ткани. Ключевые слова: пломбировочные материалы на основе цинкоксидэвгенольного цемента, воспалительная реакция, эксперименты на животных.
(1) Background: Antibiotics are used in every medical field including dentistry, where they are used for the prevention of postoperative complications in routine clinical practice during the third molar extraction. (2) Methods: This study is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The present systematic review aimed to evaluate and systematize the use of antibacterial drugs in order to prevent postoperative complications in outpatient oral surgery for wisdom teeth extraction. We conducted a systematic review using electronic databases such as Medline PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. Considering inclusion and exclusion criteria, we included randomized clinical trials published up to 2021 investigating the antibiotic prescription for third molar extraction. (3) Results: We selected 10 studies after the application of inclusion and exclusion criteria. The results showed that the most widely used antibiotic was amoxicillin both with and without clavulanic acid, in different dosages and duration. There were no statistically significant differences between treatment groups for development of postoperative complications. (4) Conclusions: Based on the analysis of the included studies, penicillin is currently the most widely prescribed group of antibiotics. The widespread use of this antibiotic group can lead to antimicrobial resistance (AMR). Due to increasing prevalence of bacteria resistance to penicillins, clinicians should carefully prescribe these antibiotics and be aware that the widespread use of amoxicillin may do more harm than good for the population.
Object: assessment of the antibacterial effect of sealing materials based on epoxy resin, zinc-eugenol of cement and hydroxide of calcium. Materials and methods: Antibacterial activity was estimated by agaro-diffusive test (ADT) estimated the of microorganisms. Plates from filling materials were placed on Petri dish, the sowed with St. aureus, and a zone of a growth inhibition of microorganisms was estimated. Materials were used right after mixing, right after hardening, in 30 days after mixing. Results: Materials had the maximum antibacterial effect after hardening, minimum in 30 days after mixing. The greatest efficiency against St. aureus showed material based on zinc-oxide- eugenol cement.
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