Histological evaluation of inflammatory response to zinc-oxide-eugenol filling materials in a soft and bone tissues

Tarasenko, S. V.; Grigor'janc, L A; Морозова, Е. А.; Gor, Ilana; Simonjan, D V; Kamilov, Sh T

doi:10.17116/stomat20199805111

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Histological analysis reveals that zinc-oxide-eugenol-based filling material supports inflammatory reaction in the tissue, but bone tissue shows statistically lower inflammatory response in comparison to soft tissue (11).…”

Section: Discussionmentioning

confidence: 95%

Elimination of root canal filling material from the root and the bone

Panov¹

2019

MedInform

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We present a case of a 43 years old male with mandibular central incisors trauma which dates back to 1985, i.e. 34 years before the current study. At that time the patient is 9 years old and the teeth are with incomplete root development. An endodontic treatment of 31 and 41 is conducted, and followed by phisioterapy. The patient has no complaints, and the first radiographic investigation is made 12 years later, in 1997. Radiograph reveals teeth with non-exact endodontic treatment-canals are over-filled and short-filled in the same time. Overextension of filling material into the surrounding bone tissues with a resorption around it on 3-4 mm apically to 31 is confirmed. Voids are present in the root filling and between root filling and root canal walls. There is a loss of the alveolar bone between 31 and 41. An endodontic revision with apical surgery is recommended, but no treatment is executed. We observe a complete absorption of over-filled canal filling material from the bone for a period of 25 years. At the 34 year we see only a slight lightening at the place of the overfilled material and an almost complete lack of canal filling of 31. 34 years after the treatment, the patient has not received any treatment and has never had any complaints. The teeth are still restored with the temporary obturation from 1985. Over time, root canal filling is eliminated not only from the bone, but from the root canals.

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Section: Discussionmentioning

confidence: 95%

Elimination of root canal filling material from the root and the bone

Panov¹

2019

MedInform

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“…Seo et al's research demonstrated that zinc treatment of osteoblastic MC3T3-E1 cells affected their proliferation, collagen synthesis, and the activity of the bone marker protein alkaline phosphatase (ALP) [25]. Furthermore, human studies indicate that oral administration of zinc at a dose of 3060 µmol/kg can increase alkaline phosphatase (ALP) activity and the DNA content of bone tissue [26,27].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair

Liu,

Yu,

Chen

et al. 2024

Biomedicines

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In orthopedics, the repair of bone defects remains challenging. In previous research reports, magnesium phosphate cements (MPCs) were widely used because of their excellent mechanical properties, which have been widely used in the field of orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped magnesium phosphate cement (ZMPC) is a novel material with good biocompatibility and degradability. This article summarizes the preparation method, physicochemical properties, and biological properties of ZMPC through research on this material. The results show that ZMPC has the same strength and toughness (25.3 ± 1.73 MPa to 20.18 ± 2.11 MPa), that meet the requirements of bone repair. Furthermore, the material can gradually degrade (12.27% ± 1.11% in 28 days) and promote osteogenic differentiation (relative protein expression level increased 2–3 times) of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. In addition, in vivo confirmation revealed increased bone regeneration in a rat calvarial defect model compared with MPC alone. Therefore, ZMPC has broad application prospects and is expected to be an important repair material in the field of orthopedic medicine.

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Histological evaluation of inflammatory response to zinc-oxide-eugenol filling materials in a soft and bone tissues

Cited by 2 publications

References 4 publications

Elimination of root canal filling material from the root and the bone

Elimination of root canal filling material from the root and the bone

Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair

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