(1) Background: Antibiotics are used in every medical field including dentistry, where they are used for the prevention of postoperative complications in routine clinical practice during the third molar extraction. (2) Methods: This study is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The present systematic review aimed to evaluate and systematize the use of antibacterial drugs in order to prevent postoperative complications in outpatient oral surgery for wisdom teeth extraction. We conducted a systematic review using electronic databases such as Medline PubMed, Scopus, and the Cochrane Central Register of Controlled Trials. Considering inclusion and exclusion criteria, we included randomized clinical trials published up to 2021 investigating the antibiotic prescription for third molar extraction. (3) Results: We selected 10 studies after the application of inclusion and exclusion criteria. The results showed that the most widely used antibiotic was amoxicillin both with and without clavulanic acid, in different dosages and duration. There were no statistically significant differences between treatment groups for development of postoperative complications. (4) Conclusions: Based on the analysis of the included studies, penicillin is currently the most widely prescribed group of antibiotics. The widespread use of this antibiotic group can lead to antimicrobial resistance (AMR). Due to increasing prevalence of bacteria resistance to penicillins, clinicians should carefully prescribe these antibiotics and be aware that the widespread use of amoxicillin may do more harm than good for the population.

This review is devoted to updating the existing knowledge about pharmacology of the drugs from the group of direct oral anticoagulants (DOACs). Special attention is paid to comparison of the anticoagulant properties of DOACs with traditional (indirect) anticoagulants at various dosage regimens and to study drug interactions of DOACs with drugs from different pharmacological groups. Widely analyzed the side effects associated with errors in the application of DOACs and provided recommendations for their correction, including the using of reversal agents therapy. Based on this, the presented article will be useful to clinicians to familiarize themselves with modern medical strategies based on the use of drugs from the DOACs group for the prevention and treatment of diseases associated with increased blood clotting ability and using of DOACs specific antagonists for treatment overdose of DOACs.

AIM: The research has been aimed at optimization of approaches to diagnosis, prevention, and treatment strategies to the hereditary dental diseases based on the analysis of modern relevant information. METHODS: Using the methods of content analysis and cluster analysis, the information included in periodicals, as well as educational and non-regulatory publications for the period of 2011–2019, was systematized and structured; the analysis of sources devoted to modern approaches to the diagnosis, prevention, and treatment of hereditary dental diseases, their genetic etiology, with the description of clinical cases and illustrations for each example, was conducted; hereditary dental diseases were classified; based on a comparative analysis, approaches to the diagnosis, treatment, and prevention of these diseases were optimized. RESULTS: The most significant hereditary dental diseases have been identified, the classification of approaches to their diagnosis and treatment has been presented, the scheme of drug therapy has been optimized depending on the pathology. CONCLUSION: The systematic analysis of information on hereditary dental diseases with the description of clinical cases for each nosology has been carried out for the 1st time, and the approaches to their diagnosis and treatment have been optimized with due consideration of domestic and foreign experience.

Drug preparations, a substance or a mixture of substances of synthetic or natural origin, are used for the prevention, diagnosis, and treatment of various diseases. Along with the benefits, drug prepararions can also have adverse side effects, identifying the causes of which is quite problematic in the practice of a dentist because of the diversity of the clinical picture. The rational use and optimal choice of a drug among a wide range of drugs depend on the profile of its effectiveness and safety, drug interaction, individual characteristics of the patient (genetic polymorphism), and other concomitant diseases. Nowadays, the practice of a dentist is impossible to imagine without the use of drugs. Drug preparations allow doctors providing quality medical care that meets international standards, but do not forget that when prescribing a drug is extremely important to consider how rationally and necessary to use it to achieve a positive result in treatment. Therefore, the study of the prevention of the development of unwanted adverse reactions of drugs in dentistry is an important topic that requires close attention. Based on the analysis of the literature on the RSCI, Scopus, Web of Science, MedLine databases, the most commonly prescribed groups of drugs in dentistry were found to be as follows: non-steroidal anti-inflammatory drugs (NSAIDs), topically anesthetizing, antimicrobial, antiseptic, and drugs. The aim of the study: On the basis of the analysis of modern information about undesirable reactions of drugs, often used in dentistry, to optimize approaches to rational use and prevention of undesirable side effects.