Prevalence and Structure of Periodontal Disease and Oral Cavity Condition in Patients with Coronary Heart Disease (Prospective Cohort Study)

Gor, Ilana; Nadeem, Gulrez; Bataev, H.M.; Дорофеев, А. Л.

doi:10.2147/ijgm.s330724

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Periodontitis is a prevalent oral disease affecting an estimated 538 million people worldwide in 2019, representing approximately 10–15% of the global population [ 1 ]. In China, according to the Fourth National Oral Health Survey [ 2 ], the prevalence of periodontitis is alarmingly high, with rates of up to 90% in children and adolescents and 97% in adults, making it one of the most serious oral diseases that negatively impact the quality of life.…”

Section: Introductionmentioning

confidence: 99%

Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

He,

Zheng,

et al. 2023

BMC Oral Health

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Background Periodontitis is the most common oral disease and is closely related to immune infiltration in the periodontal microenvironment and its poor prognosis is related to the complex immune response. The progression of periodontitis is closely related to necroptosis, but there is still no systematic study of long non-coding RNA (lncRNA) associated with necroptosis for diagnosis and treatment of periodontitis. Material and methods Transcriptome data and clinical data of periodontitis and healthy populations were obtained from the Gene Expression Omnibus (GEO) database, and necroptosis-related genes were obtained from previously published literature. FactoMineR package in R was used to perform principal component analysis (PCA) for obtaining the necroptosis-related lncRNAs. The core necroptosis-related lncRNAs were screened by the Linear Models for Microarray Data (limma) package in R, PCA principal component analysis and lasso algorithm. These lncRNAs were then used to construct a classifier for periodontitis with logistic regression. The receiver operating characteristic (ROC) curve was used to evaluate the sensitivity and specificity of the model. The CIBERSORT method and ssGSEA algorithm were used to estimate the immune infiltration and immune pathway activation of periodontitis. Spearman’s correlation analysis was used to further verify the correlation between core genes and periodontitis immune microenvironment. The expression level of core genes in human periodontal ligament cells (hPDLCs) was detected by RT-qPCR. Results A total of 10 core necroptosis-related lncRNAs (10-lncRNAs) were identified, including EPB41L4A-AS1, FAM30A, LINC01004, MALAT1, MIAT, OSER1-DT, PCOLCE-AS1, RNF144A-AS1, CARMN, and LINC00582. The classifier for periodontitis was successfully constructed. The Area Under the Curve (AUC) was 0.952, which suggested that the model had good predictive performance. The correlation analysis of 10-lncRNAs and periodontitis immune microenvironment showed that 10-lncRNAs had an impact on the immune infiltration of periodontitis. Notably, the RT-qPCR results showed that the expression level of the 10-lncRNAs obtained was consistent with the chip analysis results. Conclusions The 10-lncRNAs identified from the GEO dataset had a significant impact on the immune infiltration of periodontitis and the classifier based on 10-lncRNAs had good detection efficiency for periodontitis, which provided a new target for diagnosis and treatment of periodontitis.

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Section: Introductionmentioning

confidence: 99%

Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

He,

Zheng,

et al. 2023

BMC Oral Health

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Changes in the Dental Status of Patients With Non-Alcoholic Fatty Liver Disease

Еmelyanov

Petrushanko

2022

Ukr. Dent. Alm.

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Relevance. Periodontal disease has a close relationship with somatic diseases of various body systems. On the basis of the results of many scientific studies it has been indicated that there are common features for pathogenetic mechanisms of formation and development of generalized chronic periodontitis and chronic obstructive pulmonary diseases, cardiovascular diseases, diseases of the digestive system, and others. Against this background, it is clear that the functions of a dentist include not only restoring or whitening teeth. The active participation of the dentist in the treatment of patients with internal diseases is essential for prevention of the progression or occurrence of complications in different somatic pathology, as well as for breaking the existing comorbid connection. The prevalence of inflammatory-dystrophic periodontal diseases reaches 70-90%, and almost 70% of them are accompanied by the presence of somatic pathology in patients. Metabolic diseases, especially non-alcoholic fatty liver disease (NAFLD), are considered to be one of the most pressing problems in the world today. NAFLD is a chronic non-communicable disease that has reached a prevalence of over 30% of personns in Western Europe and the United States over the past decade. A characteristic clinical signs of this somatic pathology is the lack of a specific clinical course, which should attract the attention of the family doctor to this organ of the digestive system. Identification of dental changes in the oral cavity in patients with NAFLD allows detect the stomatological disorders, to suspect the presence of somatic pathology, and form correct tactics for cooperative activity with the physician. Goal: study the character of dental complaints and their correlation with the data of objective examination of the oral cavity in patients with non-alcoholic fatty liver disease. Materials and methods. The main group has been included 258 somatic patients with NAFLD. The prevalence age of patients in this group was 49.79 ± 0.662. In the main group, the subgroup A consisted of 177 people with steatosis; subgroup B included 81 patients with steatohepatitis. The control group consisted of 25 people without somatic pathology. The prevalence patients' age of the control group was 43.04 ± 1.378. Subjective examination methods were performed; the nature of nutrition and the level of oral hygiene were taken into account. Objective dental status was assessed by determining oral-Vermilion oral hygiene, RVI bleeding, Parma PMA, KPI, Schiller-Pisarev test. Results. Patients in the main group had grade 1–2 obesity (body mass index – 35.20±0.49) and insulin resistance (HOMA index – 6.77±0.420). The most common complaint of patients with NAFLD was bleeding gums during brushing (58.5% of patients). Bleeding cases during eating was equal to 29.5% of patients. Dry mouth bothered more than 85.0% of patients in the main group. Bad breath (halitosis) and taste distortion (dysgeusia) were common in 86.4% and 82.6% of patients with NAFLD, respectively. Patients in the control group did not have the mentioned complaints. Correlation analysis showed a direct relationship between such complaints as bad breath and bleeding gums, and body mass index (r = 0.547 p = 0.003; r = 0.458 p = 0.014, respectively) and the degree of steatosis (r = 0.520 p = 0.000 ; r = 0.415 p = 0.001, respectively) in patients with NAFLD. Conclusions. Diagnosis and treatment of dental diseases in patients with NAFLD will allow the dentist to break the "vicious circle" of comorbidity and will help in the complex therapy of such patients.

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Prevalence and Structure of Periodontal Disease and Oral Cavity Condition in Patients with Coronary Heart Disease (Prospective Cohort Study)

Cited by 2 publications

References 29 publications

Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

Identification and assessment of differentially expressed necroptosis long non-coding RNAs associated with periodontitis in human

Changes in the Dental Status of Patients With Non-Alcoholic Fatty Liver Disease

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