Clinical efficacy of hydroxyapatite toothpaste containing Polyol Germanium Complex (PGC) with threonine in the treatment of dentine hypersensitivity

Власова, Н. Н.; Samusenkov, Vadim; Новикова, И. А.; Nikolenko, Denis; Nikolashvili, Nikita; Gor, Ilana; Danilina, A. A.

doi:10.1016/j.sdentj.2022.03.001

Cited by 7 publications

(5 citation statements)

References 17 publications

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“…After our search was completed, 4 additional studies appeared in the literature that were not included in this qualitative or quantitative synthesis [ 78 , 79 , 80 , 81 ]. These studies were consistent with HAP in reducing dentin hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

2023

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Dentin hypersensitivity (DH) is a very common dental problem that can have a negative impact on the quality of life and can lead to invasive dental procedures. Prevention of DH and control of symptoms are highly desirable. Hydroxyapatite (HAP) has been shown in vitro to block dentinal tubules and in vivo to be a safe and effective additive in oral care products that reduce DH clinically. This study’s aim was to conduct a systematic review and meta-analysis of the current evidence that HAP-containing oral care products reduce DH. Databases were searched, and only clinical trials in humans were included; studies conducted in vitro or on animals were not included. Publications in a foreign language were translated and included. We found 44 published clinical trials appropriate for systematic analysis. More than half of the trials had high-quality GRADE scores. HAP significantly reduced dentin hypersensitivity compared to placebo (39.5%; CI 95% [48.93; 30.06]), compared to fluoride (23%; CI 95% [34.18; 11.82]), and with a non-significant tendency compared to other desensitizing agents (10.2%; CI 95% [21.76; −19.26]). In conclusion, the meta-analysis showed that HAP added to oral care products is a more effective agent than fluoride in controlling dentin hypersensitivity and may be superior to other desensitizers.

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Section: Discussionmentioning

confidence: 99%

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

2023

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“…In recent years, synthetic hydroxyapatite, and more specifically nanohydroxyapatite (nanoHAP), has been proposed as a better alternative due to its high biocompatibility, bioactivity, and similarity to the one already present in enamel. Thus, the effectiveness of HAP regarding remineralization has led to multiple studies discussing its presence in different oral-care products [20][21][22][23][24][25][26][27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dobrota,

Florea,

Racz

et al. 2024

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To address tooth enamel demineralization resulting from factors such as acid erosion, abrasion, and chronic illness treatments, it is important to develop effective daily dental care products promoting enamel preservation and surface remineralization. This study focused on formulating four toothpastes, each containing calcined synthetic hydroxyapatite (HAP) in distinct compositions, each at 4%, along with 1.3% birch extract. Substitution elements were introduced within the HAP structure to enhance enamel remineralization. The efficacy of each toothpaste formulation was evaluated for repairing enamel and for establishing the dynamic of the remineralization. This was performed by using an in vitro assessment of artificially demineralized enamel slices. The structural HAP features explored by XRD and enamel surface quality by AFM revealed notable restorative properties of these toothpastes. Topographic images and the self-assembly of HAP nanoparticles into thin films on enamel surfaces showcased the formulations’ effectiveness. Surface roughness was evaluated through statistical analysis using one-way ANOVA followed by post-test Bonferroni’s multiple comparison test with a p value < 0.05 significance setting. Remarkably, enamel nanostructure normalization was observed within a short 10-day period of toothpaste treatment. Optimal remineralization for all toothpastes was reached after about 30 days of treatment. These toothpastes containing birch extract also have a dual function of mineralizing enamel while simultaneously promoting enamel health and restoration.

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“…Several other dental defects and/or pathologies can cause similar DH pain symptoms [13,14], therefore a differential diagnosis other similar conditions is key. Some of these conditions are: chipped teeth, fractures in restorations and pulpal sensitivity response to cavities or restorative therapies [15].…”

Section: Introductionmentioning

confidence: 99%

“…Before discussing and applying any of the available DH treatment options, it is necessary to eradicate the eventual causative etiological factors that may be present in the patient, to prevent recurrence of the condition [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, controversies are reported in desensitizing agents comparation, and no gold-standard treatment is addressed. Study results are often contradictory and clinical indexes and/or protocols for stimuli response evaluation are multiple and different; standardization in procedures and evaluation of sensitivity would be desirable for future studies [13][14][15][16][17]. The presence of a wide array of desensitizing devices and treatment modalities for DH management is strong evidence of the fact that despite being an intensely studied phenomenon in literature, no common consensus has been reached yet regarding the gold standard treatment of DH [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Evaluation of the Use of Desensitizing Agents in the Management of Dentinal Hypersensitivity

et al. 2022

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Dentinal hypersensitivity represents one of the most widespread dental problems and symptoms in the general population. It mainly affects the age group between 18 and 65 years old, presents an incidence of 35%, and may negatively affect the oral health-related quality of life of these patients. This longitudinal study aims to measure dentinal hypersensitivity in adult patients after the use of domiciliary desensitizing devices. In this study, 52 patients were included (32 females and 20 males, mean age: 53 ± 9.4) At T0 (baseline), patients were instructed to use a desensitizing toothpaste and, at T1, 27 patients reported using sodium monofluorophosphate (1450 ppm) and arginine 8% product (product A), while 25 patients reported using a toothpaste containing n-HAp (nano-hydroxyapatite) in effective dose 2.25% and 0.15% fluoride (1500 ppm) (product B). The study was carried out through three follow up appointments, 14 days apart from one another (T1 and T2). Results showed that the air sensitivity test did not exhibit a significant difference between the time points (p > 0.05), while a significant improvement of DH was recorded for tactile, osmotic, cold thermic, acid, and omni-comprehensive tests in both groups. Both desensitizing agents were effective in reducing DH for different stimuli.

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Clinical efficacy of hydroxyapatite toothpaste containing Polyol Germanium Complex (PGC) with threonine in the treatment of dentine hypersensitivity

Cited by 7 publications

References 17 publications

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Clinical Evaluation of the Use of Desensitizing Agents in the Management of Dentinal Hypersensitivity

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