The effect of aqueous extract of Moringa oleifera leaf was studied on experimentally induced gastric ulceration in rats. Pretreatment with extract 200, 300 and 400 mg/kg bw reduced the characteristic lesions induced by indomethacin compared to untreated control group in a dose dependent manner. The effects observed could be due to the action of one or more of the phytochemicals present in the leaf extract.
Objective. To ascertain the essential oil phytochemicals of the leaf and to test for the antibacterial and antioxidant properties of dichloromethane crude extract of Barringtonia asiatica leaf. Methods. The phytochemical screening of essential oils, extraction by hydrodistillation using the Clevenger apparatus, and analysis performed by gas chromatography equipped with a flame ionization detector (GC-FID). Antibacterial activity and the inhibition rate (mm) were determined using the agar disc method against four bacterial strains using tetracycline as positive control. The antioxidant potential of dichloromethane crude extract was investigated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl. Results. The essential oil properties were reasonable with major phytochemicals like uncineol 30.9%, eicosane 27.4%, eicosane 21.6%, and 4-propyl-guaiacol 14.05%. The antibacterial activity of the dichloromethane crude extract showed broad-spectrum activity against Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Klebsiella pneumoniae with inhibition value ranges between 2.50 ± 0.10 mm and 5.00 ± 0.06 mm. The dichloromethane crude extract exhibited strong antioxidant activities when compared to the standard. Conclusions. These results suggest that the leaves of Barringtonia asiatica is composed of essential compound as well as antibacterial and antioxidant properties from the crude extract; these are possible due to the presence of some bioactive compounds in the crude extract. The species also showed a reasonable amount of natural products in the essential oils from the hydrodistillation which can as well be used in the cosmetics and food industries.
Objective: The study presented here was carried out for the evaluation of bacterial and cytotoxic potential of chloroform extract of Leaves of Leptadenia hastata. The Bacterial effects was tested against 4 bacteria namely Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Klebsielia pneumonia.
Methods:The bacterial effect of the plant Leptadenia hastata was evaluated for potential antimicrobial properties in vitro by agar well diffusion method with four standard bacterial strains. Artemia salina; a brine shrimp species; was used to asses' cytotoxic activity of the plant extract.Result: Among the subjected four bacteria; in case of Staphylococcus aureus, E. coli and Salmonella typhi; their zone of inhibition was higher (1.13 ± 0.15, 1.23 ± 0.12 and 1.03 ± 0.06) at 1000 ppm concentration. Whereas in the case of Klebsielia pneumonia, the zone of inhibition was higher (1.13 ± 0.06) at 500 ppm. The extract exhibited effectiveness against the four species of bacteria was significant. Cytotoxicity property which was reflected in LC50 value and was found to be dose dependent manner
Conclusion:The present results showed potential of the medicinal plant used by traditional herbal medical practitioners as natural anti-bacteria and can effectively be used for its significant action. It is also an effective cytotoxic agent and thus justify its use among herbal medical practitioners.
Objective: This study was carried out with an objective to investigate the antibacterial potential of five leaf extract of Leptadenia hastata plant on some bacteria.
Methods:Leptadenia hastata extracts were evaluated for potential antimicrobial properties. The leaves of the plant were extracted with n-hexane, dichloromethane, ethyl acetate, chloroform and methanol and then vaporized to give respective extracts. Antimicrobial activity against Escherichia coli, salmonella typhi, staphylococcus aureus and Klebsielia pneumonia, was determined by an agar well diffusion method. The optical density of the broth using UV mini spectrophotometer and zone of inhibition by the crude extract were determined.
Results:The results showed that of n-hexane, ethyl acetate, dichloromethane and methanol extracts of Leptadenia hastata, methanolic and chloroform extracts displayed more activity with 1.10±0.10 mm ab and 0.97±0.06 mm ab where a Significantly (p<0.05) higher compared to different extract at the same concentration b Significantly (p<0.05) lower compared to the control, than others at 25-1000 ppm per well of the extracts tested.
Conclusion:The present results showed the potential of the medicinal plant used by traditional herbal medical practitioners as natural antimicrobial agents, thus can be further used to determine the bioactive products that may provide as leads in the development of new drugs.
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