Phytochemical screening and antiulcerogenic effect of &lt;i&gt; Moringa oleifera&lt;/i&gt; aqueous leaf extract

Dahiru, Daniel; Onubiyi, J. A.; Umaru, Hauwa A.

doi:10.4314/ajtcam.v3i3.31167

Cited by 85 publications

(57 citation statements)

References 6 publications

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“…It is a prolific producer of diverse secondary metabolites including glycosides preferentially rhamnosides of carbamates, thiocarbamates, nitriles, benzyl glucosinolates, thiocyanates, isothiocyanates and oxazolidine-2-thiones. Pharmacological screening of its leaf extracts exhibited hypotensive [4], cardioprotective [5], hepatoprotective [6], antidiabetic [7] and antiulcerogenic activities [8]. The pods are hypotensive [9] while seeds showed antibacterial [10], antitumor [11], anti-inflammatory and antispasmodic activities [12].…”

Section: Introductionmentioning

confidence: 99%

Hypotensive Activity of Moringa oleifera Lam (Moringaceae) Root Extracts and its Volatile Constituents

Sana¹,

Saleem²,

Faizi³

2015

Trop. J. Pharm Res

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Purpose: To explore the hypotensive activity and chemical composition of Moringa oleifera Lam (Moringaceae) roots. Methods: The fresh roots of M. oleifera was cut into small pieces and successively extracted with petroleum ether (PE) and dichloromethane (DC). PE extract was further divided into MRP and MRP -1. DC extract showed a thick mass during evaporation which was separated as MRDC -IN. The mother liquor left was divided into MRDC and MRDC -1. All residues were analyzed by gas chromatographymass spectroscopy (GC-MS) using ZB-5 column. Identification of each extract and fraction was based on comparison of their retention indices (RI), by co-injecting authentic compounds (7, 20.3 %) , stigmastan -3, 5, diene (24, 19.32 %), methyl 14-hydroxy-5-tetradecenoate (9, 19.22 %), 1 , 11 diphenyl undecane (47, 18.78 %) and cyclopentanyl hexadecane (39, 14.44 %) were the major constituents among the various hydrocarbons, fatty acids, esters, alcohols, aldehydes, isothiocyanate, aromatics, steroids, terphenyl and sulphur-containing

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Section: Introductionmentioning

confidence: 99%

Hypotensive Activity of Moringa oleifera Lam (Moringaceae) Root Extracts and its Volatile Constituents

Sana¹,

Saleem²,

Faizi³

2015

Trop. J. Pharm Res

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“…Generally, anticancer drug candidates have bulky hydrophobic groups within their chemical structures that render them water-insoluble and may lead to formulation problems and serious therapeutic challenges, including serious complications such as embolism and respiratory system failure due to the precipitation of the drug in the case of intravenous administration (33)(34)(35). For these reasons, increasing the water solubility of anticancer agents and developing soluble bioactive compounds with strong anticancer activities is vital.…”

Section: Introductionmentioning

confidence: 99%

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

2015

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Abstract. It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non-small cell lung cancer. In the present study, the anticancer activity of M. oleifera leaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP-ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays, it was demonstrated that M. oleifera leaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44-52%) the proliferation of the HepG2 cells and A549 non-small cell lung cancer cells. These results support the potential of soluble extracts of M. oleifera leaf as orally administered therapeutics for the treatment of human liver and lung cancers.

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“…This finding has justified the use of these two plants in ethnomedicine for treating infectious diseases and inflammatory conditions. Both activities investigated for the two plants may be attributed to the presence of tannins, saponins, flavonoids and alkaloids in the plants, as revealed by preliminary phytochemical investigation using established methods (Dahiru et al, 2006).…”

Section: Antimicrobial Activitymentioning

confidence: 89%

Anti-Inflammatory And Antimicrobial Activities Of Hippocratea indica Root Bark And Poga oleosa Fruits

Ogbole

Ekor²,

Oluremi³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for antiinflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent antiinflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants.

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Phytochemical screening and antiulcerogenic effect of <i> Moringa oleifera</i> aqueous leaf extract

Cited by 85 publications

References 6 publications

Hypotensive Activity of <i>Moringa oleifera</i> Lam (Moringaceae) Root Extracts and its Volatile Constituents

Hypotensive Activity of <i>Moringa oleifera</i> Lam (Moringaceae) Root Extracts and its Volatile Constituents

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

Anti-Inflammatory And Antimicrobial Activities Of <i>Hippocratea indica</i> Root Bark And <i>Poga oleosa</i> Fruits

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