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Hepatoprotective effect of an ethanolic extract of Pongamia Pinnata on antitubercular drugs (isoniazid and rifampin) induced hepatotoxicity in rats. Methods: The experiment used five groups of male wistar rats, each with six individuals. The two control groups were given gum acacia and a mixture of isoniazid and rifampin. The two test groups received 200 and 400 mg/kg of an ethanolic extract of the leaves of Pongamia Pinnata, respectively. The fifth group was given silymarin (50mg/kg, orally). The concentrations of serum Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline Phosphatase (ALP), tissue Malondialdehyde (MDA) & thiols were calculated. One-way ANOVA was used for statistical examination, monitored through Tukey's test. Results: When rats were given a mixture of antitubercular drugs and a high dosage (400 mg/kg) of an ethanolic extract of Pongamia Pinnata, blood enzyme levels were lower than when they were given antitubercular drugs alone. The co-administration of a high dose of Pongamia Pinnata extract with antitubercular drugs reduced MDA levels and elevated thiol levels considerably (p˂ 0.05). These biochemical marker levels, however, were not adjusted. Conclusion: In rats, Pongamia Pinnata encompasses a partial protective effect against the hepatotoxicity caused by antitubercular drugs at high doses.

Objectives: -The goal of this study was to see if an aqueous extract of Pongamia Pinnata Linn. (APP) leaves could protect against the hepatotoxicity caused by anti-TB medications (ATM). Methods: -In order to cause hepatotoxicity in rats, anti-tubercular medications were utilised. Silymarin (100 mg/kg p.o.) be present utilised by means of the control medication. For 21 days, an aqueous extract of Pongamia Pinnata Linn. leaves (200 & 400 mg/kg p.o.) was given with anti-TB medicines given one hour before to the aqueous extract. Results: -Biomarker enzymes found in the liver are SGPT, SGOT, ALP, Total Bilirubin & total cholesterol remained raised on anti-TB medicines management. The management of aqueous extract of Pongamia Pinnata Linn.leaves200 mg/kg & 400 mg/kg with anti - TB medicines were considerably decreased biomarker enzymes found in the liver. Antioxidant factors like Super Oxide Dismutase (SOD), Glutathione(GSH), Catalase(CAT), Glutathione Peroxidase (GPx)& Glutathione Reductase(GRx) were inhibited and improved ThioBarbituric Acid Reactive Substances (TBARs)points in anti-TB medicines administration then returned these antioxidant points in the management of aqueous extract of Pongamia Pinnata Linn. Leavesatadosageof 200mg/kg& 400mg/kg. Conclusion: - According to the findings of this research, Pongamia Pinnata Linn. leaves have a protective consequence against hepatotoxicity caused through anti-TB medicines.

The goal of this investigation was to examine if an ethanolic extract of Annona squamosa has any hepatoprotective benefits in rats suffering from isoniazid-rifampin induced hepatotoxicity. Methodology: The rats were separated in five groups (n=6): group 1, a control; group 2 administered isoniazid (100 mg/kg, I.P.) & rifampin (100 mg/kg, I.P.) in sterile water; group 3 as a control & traditional silymarin, 2.5 mg/kg, B.W., P.O.; groups 4 & 5 are treated & received 200 & 400 mg/kg, B.W., P.O., ethanolic extract of AS. All of the treatment procedures were monitored for a total of 21 days after the rats were slaughtered & Biochemical & histological investigations were performed on the blood & liver respectively. Results: Rats (Group - 2) treated with Rifampin (RIF) & Isoniazid (INH) elevated their blood Serum Glutamic Oxaloacetic Transferase (SGOT), Serum Glutamate pyruvic transaminase (SGPT) & Alkaline Phosphatase (ALP) levels during a variety of ways. The consumption of ethanolic extracts of Annona squamosa considerably reduced Rifampin & Isoniazid induced elevations in serum diagnostic liver marker enzymes. SGOT, SGPT & ALP are the three involved enzymes. Furthermore, the medical care groups had significantly larger total macromolecule & total albumen levels. The extract result was compared thereto of Silymarin, a standard medication. The histological profile backed up the changes in biochemical markers. An ethanolic extract of Annona squamosa has been discovered to protect rats from oxidative liver injury caused by rifampin & isoniazid. Conclusion: The ethanolic extract of AS protects rats from isoniazid & rifampin induced oxidative liver injury.