Dementia is a set of symptoms that include worsening of the routine of cognitive tasks, learning, reproducibility, and gait disturbances beyond typical aging. Activated c AMP can produce anti-apoptosis activity, neuroprotective activity, motor improvement, and cognitive enhancement activity. Cilostazol can increase c AMP levels, so this study aimed to evaluate the influence of cilostazol on learning-memory and motor coordination by rodent models. The rats were divided into 5 and 6 groups with 6 rats in each to test the hypothesis respectively. Before MES seizure induction the rats were trained for conditioned avoidance response for 14 days and the best one was selected for assessment. The performance of intervention treated groups to determine the memory retention effect was measured by applying a fixed number of shocks. The intervention treated groups were tested for motor coordination performance by rotarod test (4-45 RPM accelerating speed for 5 min) after 30 and 60 min. The latency time of each rat falls off from the rod for the first time was noted. The results were presented as Mean ± SD, tested by ordinary two way ANOVA followed by Tukey's multiple comparisons test. Cilostazol 100 mg/kg p.o demonstrated a significant memory enhancement activity in the conditioned avoidance response technique. Cilostazol 20mg/kg i.p alone and along with diazepam 2 mg/kg demonstrated a significant motor coordination performance in both sessions. The present study concludes that cilostazol has improved the learning & memory and motor coordination performances.
Acne vulgaris is a common dermatological problem. The choice of proper treatment is determined by the severity and extent of acne. Moderate to severe acne vulgaris cases respond well to systemic antibiotics. Antibiotics execute their anti-propionic bacterium effect by inhibiting the bacterial growth and colonization of pilosebaceous glands and thus further inflammation is prevented. The efficacy and possible side effects of various oral antibiotics has been the subject of numerous studies for at least the last twenty years in an effort to understand, which products are likely to produce better efficacy with least possible side effects. The new emerging problem is antibiotics resistance to propionic bacterium. There has been a constant increase in search of safe medications to overcome the side effects and resistance of existing formulations for the treatment of acne vulgaris. The study duration was 8 weeks. A total of 200 study participants of both sexes with complaints of acne vulgaris were included in the study and randomized into two groups. Group I (100 study subjects) – 500 mg Azithromycin once daily for three consecutive days in a week for 2 months and Group II (100 study subjects) –100 mg Doxycycline once daily for 2 months. After doing initial laboratory tests treatment was initiated. Three scheduled visits – Baseline, at the end 4th week and at the end of study were done and the response to treatment was evaluated. The efficacy of the drugs was assessed by the change in grading of acne from baseline and at follow up visits. Doxycycline was found to be better than azithromycin pulse therapy in reducing acne severity. During the visits gastrointestinal, dermatological and other side effects were also noted and recorded. Adverse event profile of both the drugs showed that there was no non- compliance incidence due to adverse event. But the number of adverse events was higher in doxycycline group.
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