Antioxidant and hepatoprotective activities of Pongamia pinnata (PP) Linn. leaves on anti-tubercular medicines (isoniazid & rifampin) induced hepatotoxicity in Wistar rats

Abstract

Objectives: -The goal of this study was to see if an aqueous extract of Pongamia Pinnata Linn. (APP) leaves could protect against the hepatotoxicity caused by anti-TB medications (ATM). Methods: -In order to cause hepatotoxicity in rats, anti-tubercular medications were utilised. Silymarin (100 mg/kg p.o.) be present utilised by means of the control medication. For 21 days, an aqueous extract of Pongamia Pinnata Linn. leaves (200 & 400 mg/kg p.o.) was given with anti-TB medicines given one hour before to the aqueous extract. Results: -Biomarker enzymes found in the liver are SGPT, SGOT, ALP, Total Bilirubin & total cholesterol remained raised on anti-TB medicines management. The management of aqueous extract of Pongamia Pinnata Linn.leaves200 mg/kg & 400 mg/kg with anti - TB medicines were considerably decreased biomarker enzymes found in the liver. Antioxidant factors like Super Oxide Dismutase (SOD), Glutathione(GSH), Catalase(CAT), Glutathione Peroxidase (GPx)& Glutathione Reductase(GRx) were inhibited and improved ThioBarbituric Acid Reactive Substances (TBARs)points in anti-TB medicines administration then returned these antioxidant points in the management of aqueous extract of Pongamia Pinnata Linn. Leavesatadosageof 200mg/kg& 400mg/kg. Conclusion: - According to the findings of this research, Pongamia Pinnata Linn. leaves have a protective consequence against hepatotoxicity caused through anti-TB medicines.