Oculohypotensive effect of oral amlodipine in hypertensive individuals associated with increased intraocular pressure

The effect of Calcium channel blocker in the Betamethasone-induced Glaucoma model in rabbits

“…Prabhakar and co-workers display a topical administration of Diltiazem 0.5% and verapamil 0.1% decrease the IOP in steroid-induced glaucoma model of rabbits [18]. Furthermore, another study the Prabhakar shows a good oculo-hypotensive action of orally administered Amlodipine in a patient with IOP of more than 25 mmHg [19]. Additionally, Waleed and co-workers show an obvious drop in the IOP of topical Nimodipine in the Betamethasone-induced model of glaucoma [7].…”

“…Besides, by inhibiting endothelin-1, CCB can enhance blood flow in the eye. [18][19][20][21] Nevertheless, the impact of CCB on IOP stays debatable [22]. Calcium inflows may perhaps have many effects on the dynamics of aqueous humor, which include ciliary body perfusion, a hydrostatic element created by the pressure of the blood, and an osmotic component induced by ciliary epithelium on active sodium, calcium, and other ions secretions [7].…”

“…CCBs play an important role in retinal relaxation leading to improve ocular circulation [26]. The Santafe et al's study shows that CCBs minimize secretion of aqueous humor [19]. CCB can inhibit the normal formation of aqueous humor through the interference of gap junctions between pigmented epithelial cells and non-pigmented epithelial cells, which will lead to changes in the cell permeability of the ciliary epithelium [17].…”