Prescribing pattern of antipsychotic medications in patients with schizophrenia in a tertiary care hospital

Sushma, H. K.; Jyothi, C. H.; Somashekar, H. S.; Avanthi, E.; Imran, Muhammad; Raja, B. William Dharma

doi:10.5455/2319-2003.ijbcp20150224

Cited by 7 publications

(11 citation statements)

References 16 publications

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“…In present study among 310 patients, a male: female ratio of 1.3:1 was seen. Present study finding of male preponderance was similar other studies done in Maharashtra by Sushma HK et al, and also by Thakare et al 27,28 However this finding is different from studies done in Indore by Atal S et al, and in Gujrat by Galani VJ et al 29,30 Majority of the patients were below 40 years of age (65%) whereas only 35% of the patients were above 40 years of age. In addition to this, present study findings depicted that schizophrenia has an early age of onset, affecting males in their early twenties and females in their late twenties and early thirties.…”

Section: Discussionsupporting

confidence: 75%

“…Present study finding regarding favoured use of atypical anti-psychotics is in concordance with other authors in the field but in contrast to Sushma HK et al, who concluded that typical anti-psychotics were prescribed more as compared to atypical antipsychotics. 27,34,35 Olanzapine (31%) was the most frequently prescribed medication amongst anti-psychotics followed by risperidone (26%), quetiapine (12%), haloperidol (10%), amisulpiride (8%), aripiprazole (8%) and iloperidone (5%).…”

Section: Discussionmentioning

confidence: 99%

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Drug utilization audit of antipsychotics using WHO methodology: recommendations for rational prescribing

Shaifali

Karmakar

Chandra

et al. 2018

Int J Basic Clin Pharmacol

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Background: Utilization pattern of antipsychotics has undergone a major shift as the newly introduced atypical antipsychotics have heralded the market. Hence continuous studies on current prescribing trends are needed to provide most updated, effective and rational treatment of psychoses.Methods: This cross-sectional prospective study was conducted at Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India. OPD tickets of the department of psychiatry for the year 2016-2017 were evaluated for a total of 310 cases. These prescriptions were used to determine the drug utilization of antipsychotics and for their appropriateness against the WHO recommended core prescribing indicators.Results: A total of 310 patients satisfied the inclusion criteria and a male predominance was seen (male:female= 1.3:1). The most common psychotic disorder diagnosed was schizophrenia (44%). Majority of the patients (76%) received monotherapy and the prescribing trend showed a higher use of atypical antipsychotics (89%) over typical ones (11%). The most commonly prescribed anti-psychotic drugs were olanzapine (31%), followed by risperidone (26%). On analysing prescriptions according to the WHO core prescribing indicators it was observed that average number of antipsychotics prescribed per prescription was 1.32. 24% of drugs were prescribed by generic name and 5.2% were administered via injectable route. Drugs prescribed from National list of Essential Medicine, 2015 constituted 46%.Conclusions: The high inclination towards the use of atypical antipsychotics observed in our study correlates with the global changing trends in the treatment of schizophrenia. WHO prescribing indicators should be adhered to, to impart rational prescribing.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Drug utilization audit of antipsychotics using WHO methodology: recommendations for rational prescribing

Shaifali

Karmakar

Chandra

et al. 2018

Int J Basic Clin Pharmacol

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“…Considering the prescribing pattern of antipsychotic medications in our study, it was identified that majority (86%) of the patients were prescribed with combination therapy as compared to monotherapy (14%) which is comparable to the findings of other studies. 14,17,20 Even though the guidelines recommend initiating the treatment with only one antipsychotic medication at a time, many of the times the use of combination of antipsychotic medications might be required to achieve greater therapeutic responses when the use of single antipsychotic drug provides unsatisfactory response and also due to the complexity of the clinical presentation.…”

Section: Discussionmentioning

confidence: 99%

“…Our study has shown a lower prescription rate of anticholinergics as compared to other studies that showed a range between 5.5-94%. 14,20,22,24,27,28 World health organization treatment guidelines do not recommend routine use of anticholinergics in patients with psychiatric illness who are on antipsychotics but use only for short term in selected cases. it should only be used in patients who are on high potency antipsychotics, having a previous history of extrapyramidal side effects or develops EPS and showing no improvement even after switching to another antipsychotic drug.…”

Section: Discussionmentioning

confidence: 99%

Trends and practices in prescribing anti-psychotropic medications in hospitalized patients with psychiatric disorders in a secondary care hospital in Ras al Khaimah

Shareef

Rao

Ayman

2020

Int J Basic Clin Pharmacol

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Background: Advances in the psycho-pharmacotherapy enhance the development of newer and better drugs in the management of psychiatric disorders. However, their proper utilization, safety and efficacy and adverse effects in the clinical practice needs continuous study. The study aimed to assess the trends and practice of prescribing psychotropic medications in hospitalized patients in a secondary care hospital in Ras Al Khaimah.Methods: A prospective observational study was carried out for a period of six months in a psychiatry department. All the patient details including the demographic data and prescribing pattern of antipsychotic medication were collected from the patient case records and were later analysed by using descriptive statistics.Results: A total of 50 patient’s prescription were analysed during the study period. Male (54%) predominance was noted over females (46%) with majority (64%) of patients were in the age group of 21-40 years. Schizophrenia (35.8%) was the most common psychiatric disorders followed by affective disorders (30.86%). The average number of psychiatric drugs per prescription was found to be 3.38±1.23. Antipsychotics (43.36%) were the commonly prescribed class of medications followed by mood stabilizers (12.38%) and anxiolytics (11.06%) with olanzapine (n=26), sodium valproate (n=21) and clonazepam (n=9) being frequently prescribed medications. Escitalopram (n=9) was the most commonly used anti-depressants. Combination therapy (86%) is preferred over monotherapy (14%).Conclusions: This study helps to assist in ensuring rational drug therapy and reducing the incidence of drug related problems and medication errors and thereby enhancing the quality of care in patients with psychiatric disorders.

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“…The combination of antipsychotics may include concomitant use of more than one drug which may be a combination of typicals or atypicals. It may also involve the prescription of atypical and typical antipsychotics together as well as combination with mood stabilizers, anxiolytics, anticholinergics and antidepressants [15,23]. The frequency of antipsychotic combination therapy vary widely often ranging from 9 -94% [23,24,25].…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic Drugs Prescription Pattern among Patients with Schizophrenia in a Federal Neuropsychiatric Hospital Maiduguri, North East Nigeria

Onah

Abdulmalik

Kaigamma

2018

JAMPS

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Introduction: Schizophrenia is a mental disorder characterised by delusions, disorganised thought and speech, hallucinations, blunted affect and reduced motivation among other clinical manifestations. Antipsychotic medications have demonstrated effectiveness in reducing symptoms and improvement in the quality of life of patients. In recent years emphasis has been shifting to using atypicals as first-line therapy primarily because of their ability to improve both positive and negative symptoms and reduced incidence of side effects. In Nigeria, there is paucity of data as to whether or not if this transition is taking place and to what extent. Objectives: To determine the antipsychotic drugs prescription pattern, assess the extent of prescription of atypicals as well as determine level of co-prescribed medications. Methods: This was a cross-sectional retrospective study carried out in Federal neuropsychiatric hospital, Maiduguri. The sample size of 360 was used [Taro Yamane formula] and medical records Original Research Article

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Prescribing pattern of antipsychotic medications in patients with schizophrenia in a tertiary care hospital

Cited by 7 publications

References 16 publications

Drug utilization audit of antipsychotics using WHO methodology: recommendations for rational prescribing

Drug utilization audit of antipsychotics using WHO methodology: recommendations for rational prescribing

Trends and practices in prescribing anti-psychotropic medications in hospitalized patients with psychiatric disorders in a secondary care hospital in Ras al Khaimah

Antipsychotic Drugs Prescription Pattern among Patients with Schizophrenia in a Federal Neuropsychiatric Hospital Maiduguri, North East Nigeria

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