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The voltammetric behavior of ramipril (RMP), an angiotensin‐converting enzyme inhibitor, was investigated for the first time in the literature on a boron‐doped diamond electrode (BDDE) using cyclic (CV) and square‐wave voltammetry (SWV). Its behavior was also considered in the presence of a thiazide diuretic, hydrochlorothiazide (HCTZ), for the simultaneous determination. The performance of BDDE and glassy carbon electrode (GCE) was compared, since RMP provides a high oxidation potential. It was observed that the anodic peak potentials for HCTZ and RMP at the BDDE were 1.23 and 1.67 V (vs. Ag/AgCl (3.0 mol L‐1 KCl)) by CV in BR buffer solution (pH 2.0), respectively. The influence of supporting electrolyte, pH and scan rate in the current response of these both drugs was examined to select optimum experimental conditions. By this way, the determination of RMP and its association with HCTZ using SWV and a BDDE was successfully applied in real samples (single and combined dosage forms), with results in close agreement at 95% confidence level with those obtained using high‐performance liquid chromatography.

An electrochemical sensor using glassy carbon electrode modified with carbon black within a poly(allylamine hydrochloride) film is proposed in this work. The novel sensor was characterized by scanning electron microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry using the redox probe Fe(CN)63−/4−. The sensor was applied for the simultaneous determination of dopamine (DA), paracetamol (PAR), amlodipine (AML), and rosuvastatin (RSV). The quantification of all four analytes was carried out by linear sweep voltammetry and presented a linear concentration range for all analytes from 1.0 to 90 μmol L−1, with limit of detection of 0.55, 1.3, 5.7, and 3.0 μmol L−1 for DA, PAR, AML, and RSV, respectively. This sensor was successfully applied in the simultaneous determination of these analytes in environmental, pharmaceutical, and biological samples.

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