Glassy Carbon Electrode Modified with Layering of Carbon Black/Poly(Allylamine Hydrochloride) Composite for Multianalyte Determination

Abstract

An electrochemical sensor using glassy carbon electrode modified with carbon black within a poly(allylamine hydrochloride) film is proposed in this work. The novel sensor was characterized by scanning electron microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry using the redox probe Fe(CN)63−/4−. The sensor was applied for the simultaneous determination of dopamine (DA), paracetamol (PAR), amlodipine (AML), and rosuvastatin (RSV). The quantification of all four analytes was carried out by linear sweep voltammetry and presented a linear concentration range for all analytes from 1.0 to 90 μmol L−1, with limit of detection of 0.55, 1.3, 5.7, and 3.0 μmol L−1 for DA, PAR, AML, and RSV, respectively. This sensor was successfully applied in the simultaneous determination of these analytes in environmental, pharmaceutical, and biological samples.

Comparison of Carbon Nanomaterials for Simultaneous Detection of Neurotransmitters in the Presence of Interfering Species

“…Detection limit [μM] GCE 2.5-50 (2.5-90) [31] 0.25(� 0.02) (0.15) [31] 1.614(� 0.211) (1.0) [31] GCE/CB 0.25-10 (1.0-22) [32] 7.77(� 1.13) (0.38*) [32] 0.196(� 0.030) (0.55) [32] GCE/GO 0.1-10 (1.0-40) [33] 74.87(� 4.19) (0.318*) [33] 0.084(� 0.011) (0.69) [33] GCE/CND 0.75-20 (0.15-150) [27] 0.403(� 0.04) (3.74*) [27] 0.503(� 0.123) (0.026) [27] * μA/μM ChemElectroChem nounced with increasing concentration of 5-HT. Again, electrodes coated with carbon black produce a shifting baseline.…”

Application of botryosphaeran as a carbon black adherent on a glassy carbon electrode for the electrochemical determination of cyclobenzaprine

“…Initially, CB was dispersed in DMF, which is a better approach to disperse CB in DMF than water [34]. A dispersion of 2 mg CB in 1 mL of DMF was prepared in an ultra-sonic bath for 1 h at room temperature.…”

Black phosphorus nanosheets/poly(allylamine hydrochloride) based electrochemical immunosensor for the selective detection of human epididymis protein 4

“…Recently, the development of biosensors based on polyelectrolytes-nanomaterials composites gained much attention from scientific community; for example, Zhao et al have demonstrated enzymatic electrochemical biosensor based on poly-L-lysine/black phosphorus hybrid [38]. Scremin et al have developed poly(allylamine hydrochloride)/carbon black composite based electrochemical sensor to detect multi-analytes [39]. Polyelectrolyte films have the advantage of lessen the effect of the interferences having opposite charge to analyte that could reach the electrode surface.…”