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The simultaneous voltammetric determination of antihypertensive drugs amlodipine besylate (AML) and atenolol (ATN) using a cathodically pretreated boron-doped diamond electrode (CP-BDDE) is reported for the first time. The anodic peak potentials of AML and ATN at a CP-BDDE were found to be 0.727 and 1.32 V (vs. Ag/AgCl (3.0 mol L -1 KCl)) in phosphate buffer (pH 7.0), respectively, by cyclic voltammetry. It was observed that the CP-BDDE possesses improved performance for the simultaneous determination of AML and ATN when compared to other carbon-based electrodes in these conditions. Using square-wave voltammetric technique, the obtained analytical curves were linear in the concentration range from 2.9-33 µmol L -1 for AML and 9.8-190 µmol L -1 for ATN, with limits of detection of 0.17 and 0.22 µmol L -1 , respectively. The proposed method was successfully applied to the simultaneous determination of AML and ATN in pharmaceutical samples.

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For the first time, a boron-doped diamond electrode was used to indapamide hydrochloride sensing.