Sensitive square-wave voltammetric determination of tadalafil (Cialis®) in pharmaceutical samples using a cathodically pretreated boron-doped diamond electrode

Sartori, Elen Romão; Clausen, Débora Nobile; Pires, Igor Matheus Ruiz; Salamanca-Neto, Carlos Alberto Rossi

doi:10.1016/j.diamond.2017.07.001

Cited by 44 publications

(14 citation statements)

References 34 publications

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“…On reviewing literature, TMS was quantified by several methods, namely; TLC [16][17][18], HPLC in different matrices [18][19][20][21], capillary electrophoresis [16], spectrophotometry [16,[22][23][24], and electrochemical methods [16,25]. For TAD, several methods were reported for its determination includ-ing TLC [26][27][28][29], HPLC [26,[30][31][32][33][34][35][36], gas chromatography [26,37], capillary electrophoresis [26], spectrophotometry [26,[38][39][40][41], and electrochemical methods [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Stability assessment of tamsulosin and tadalafil co‐formulated in capsules by two validated chromatographic methods

Rezk

Abdel-Moety

Wadie

et al. 2020

J of Separation Science

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The advent of a new pharmaceutical formulation evokes the need for examining the chemical stability of their constituents and establishing proper stability‐indicating methods. Herein, the stability of the newly co‐formulated Tamsulosin and Tadalafil were examined under different stress conditions. The acidic degradation of Tamsulosin yielded its sulfonated derivative, while Tadalafil was susceptible to both acidic and basic degradation. Two stability‐indicating chromatographic methods, namely; high‐performance thin‐layer chromatography and high‐performance liquid chromatography, have been developed. Significant high‐performance thin‐layer chromatography‐fractionation could be achieved by utilizing a stationary phase of silica gel 60 F254 and a mobile phase composed of ethyl acetate/toluene/methanol/ammonia (4:2:4:0.6, by volumes) with densitometric recording at 280 nm over a concentration range of 0.5–25 μg/band for both drugs. The HPLC‐separation could be reached on XBridge® C18 column isocraticaly by using a mobile phase having acetonitrile/phosphate buffer, pH 6.0 (45:55, v/v) pumped at a flow rate of 1.7 mL/min and applying diode array ultraviolet‐detection at 210 nm over a linearity range of 3–70 μg/mL for each drug. Specificity of the two methods was additionally assured via peak purity assessment. Moreover, the methods were distinctly exploited for evaluating the drugs’ stability in accelerated stability‐studied samples of Tamplus® capsules.

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Section: Introductionmentioning

confidence: 99%

Stability assessment of tamsulosin and tadalafil co‐formulated in capsules by two validated chromatographic methods

Rezk

Abdel-Moety

Wadie

et al. 2020

J of Separation Science

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“…However, the linearly range obtained for TDL in the proposed BIA method was one of the higher in comparison to other voltammetric methods. As a proof of the concept, the obtained linearly range in the BIA‐AD with the cathodically pretreated BDD was around 120‐fold times higher in comparison to the same electrode at a stationary voltammetric cell (SWV detection) , endorsing the capability of hydrodynamic systems to minimize the working electrode poisoning (reduced time of contact between the fouling agent and sensor) . The proposed BIA methods are more versatile (can be used for qualitative investigation of TDL purity and TDL determination), more simple (does not require complex procedures for electrode modification) and presents the highest analytical frequency (270 injections per hour) in comparison to other reported EM for TDL, a result of the very fast hydrodynamic mass transport (BIA) and instantaneous oxidation of TDL over the H‐BDD surface (AD).…”

Section: Resultsmentioning

confidence: 99%

“…In this scenario, electroanalytical methods (EM) are attractive, once they present simplicity, sensitivity, low consumption of reagents, relative low cost, and portable instruments. Few EM were reported in literature for TDL determination in pharmaceutical products, using pulsed voltammetric detection under stationary conditions at unmodified [15] and modified carbon electrodes [16,[17][18][19]. Furthermore, any of such works aims the screening of TDL (only for determination in authentic pharmaceutics for quality control purposes).…”

Section: Introductionmentioning

confidence: 99%

Fast Screening and Determination of Tadalafil in Pharmaceutics by Batch Injection Analysis (BIA) with Amperometric Detection

et al. 2020

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Tadalafil (TDL) is the active ingredient of Cialis ® , one of the top selling drugs for the treatment of erectile dysfunction and very counterfeit worldwide. In this work, two amperometric methods are proposed for (1) determination and (2) screening of TDL in pharmaceutical products using a boron-doped diamond electrode assembled in a 3Dprinted Batch Injection Analysis cell. Cyclic voltammograms showed that TDL presented one irreversible oxidation and pH dependent process at about 1.0 V (vs Ag/AgCl) with maximum current in Britton-Robinson buffer pH 4.0. For the method 1, a constant potential of + 1.3 V was applied and, under optimized conditions, good linear range for TDL quantification (from 1.0 to 150.0 μmol L À 1), LOD of 1.0 μmol L À 1 (experimental), high repeatability (RSD = 1.9 %; n = 20) and good sample throughput (270 h À 1) were obtained. Method 1 was used for the determination of TDL in genuine and generic formulations, and the results were not statistically different from a comparative spectrophotometric method at a 95 % confidence level. In method 2, the multiple pulse amperometric detection (MPAD) was taken through the application of sequential potential pulses (+ 1.0, + 1.2 and + 1.5 V). The comparative profile of each sample was done after peak ratios from each amperogram (R 1 = i pa1.2V /i pa1.0V , R 2 = i pa1.5V /i pa1.2V , R 3 = i pa1.5V /i pa1.0V). This simple current normalization allowed the recognition of similar profiles between samples containing only TDL and differences between samples adulterated with other drugs (sildenafil, paracetamol, dipyrone, and caffeine). Finally, these methods are fast, use portable low-cost apparatus and unmodified electrodes. Such features are attractive for routine analysis in forensic and pharmaceutical sciences.

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“…Tadalafil (TDL) is used for treating benign prostatic hyperplasia. This pharmaceutical was quantified by Sartori and coauthors using SWV methodology . The authors used BR buffer (pH 4) on BDD electrodes (doping level of 8000 ppm).…”

Section: Electroanalysis Of Pharmaceuticalsmentioning

confidence: 99%

Electroanalysis of Pharmaceuticals on Boron‐Doped Diamond Electrodes: A Review

et al. 2019

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diamond (BDD) electrodes possess outstanding physical, chemical, and electronic properties and have been successfully, yet in a limited way, explored in the electroanalysis of substances with therapeutic action (analgesics, antipyretics, antibiotics, anti-inflammatories, antihypertensives, antidepressants, vitamins, and others) in diverse milieus (pharmaceutical formulations, urine, serum, whole blood, surface waters, seawaters, groundwater, wastewaters, etc.). Therefore, in this Review, a broad overview of the available scientific information on recent progress and achievements of the application of bare or modified BDD electrodes to the bioanalytical and environmental detection of pharmaceutical compounds is presented. The main parameters, for example boron concentration, applied operational conditions during pretreatment, chemical and physical structure, and other influential factors on the electroanalytical BDD electrodes performance, are discussed.[a] Dr.

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Sensitive square-wave voltammetric determination of tadalafil (Cialis®) in pharmaceutical samples using a cathodically pretreated boron-doped diamond electrode

Cited by 44 publications

References 34 publications

Stability assessment of tamsulosin and tadalafil co‐formulated in capsules by two validated chromatographic methods

Stability assessment of tamsulosin and tadalafil co‐formulated in capsules by two validated chromatographic methods

Fast Screening and Determination of Tadalafil in Pharmaceutics by Batch Injection Analysis (BIA) with Amperometric Detection

Electroanalysis of Pharmaceuticals on Boron‐Doped Diamond Electrodes: A Review

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