<p><strong>Aim <br /></strong>To provide evidence regarding the effectiveness of aripiprazole in improving penile erection with a therapeutic strategy of<br />add-on or switching therapy in patients with schizophrenia.<br /><strong>Methods<br /></strong>PubMed, Cochrane, Clinical Key, ProQuest, EBSCOhost, and ScienceDirect were searched for any design study that<br />evaluated aripiprazole only or versus control (placebo or other antipsychotic) for erectile dysfunction in patients with schizophrenia. Three studies were identified and analysed from 295 initial articles. Data were then extracted from the studies and summarized descriptively.<br /><strong>Results</strong> <br />Two hundred ninety-five articles were screened, and three studies were identified and eventually selected. After the add-on or switching antipsychotic therapy to aripiprazole, the prevalence of erectile dysfunction and the score of erectile dysfunction or penile erection assessed by Nagoya and Sexual Function Questionnaire (NSFQ) and Arizona Sexual Experience Scale (ASEX) decreased.<br /><strong>Conclusion</strong> <br />Aripiprazole was effective to improve penile erectile function in patients with schizophrenia. The therapeutic strategy is<br />adjunctive treatment or switching therapy to aripiprazole.</p>
Introduction: Diabetes can be caused by inflammatory regulation disorders. Metformin has been reported that inhibits the physiological function of normal cells. Asiatic acid, a bioactive compound from Centella asiatica, has the potential to be developed as a therapeutic agent for diabetes, but little is known about its toxic effects on macrophage cells and fibroblast cells. Objective: The study aims to evaluate the toxic effects of Asiatic acid and metformin on the viability of RAW264.7 macrophage cells and NIH3T3 fibroblast cells. Method: Asiatic acid and metformin with seven concentrations were given to RAW264.7 macrophage cell lines and NIH3T3 fibroblast cell lines. Viability percentage is calculated using the 3- (4, 5-dimethylthiazol-2-il) -2, 5-diphenyltetrazolium bromide method, and the absorbance is measured at 595nm. Results: Results have shown that Asiatic acid with concentrations> 12.5 μg/mL decreases the viability of RAW264.7 and NIH3T3 cells drastically. RAW264.7 and NIH3T3 cells that had been given metformin concentrations of 11.6 μg/mL to 370 μg/mL still showed a large percentage of cell viability. Conclusion: Asiatic acid has shown that the cytotoxic effect is greater than metformin, so it is necessary to pay attention to the concentration of the treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.