Objective: Wheezing is a common and challenging health issue in infancy and early childhood. Asthma diagnosis is frequent in patients with a history of recurrent wheezing. A relationship has been reported between asthma and anti-inflammatory mediators such as lipoxin A4 and annexin A1. However, this remains uncertain in wheezy infants. The aim of the present study was to determine lipoxin A4 and annexin A1 levels in wheezy infants. Materials and Methods: Eighty-seven patients aged 6-36 months were included in this study. Demographic characteristics, clinical features, laboratory data, clinical diagnoses, and treatments, if present, were recorded. Patients were divided into 2 groups: patients with wheezing (n = 59) and healthy controls (n = 28). Blood samples were taken and lipoxin A4 and annexin A1 levels were evaluated by ELISA. Results: Lipoxin A4 and annexin A1 levels were significantly lower in the wheezing group than in the control group (p < 0.05). A significant correlation was found between the serum total immunoglobulin E (IgE) level and the percentage and absolute number of eosinophils (p < 0.05). No significant correlation was found in terms of lipoxin A4 and annexin A1 levels, the serum total IgE level, and the percentage and absolute number of eosinophils among groups (p > 0.05). Conclusion: This is the first study to assess lipoxin A4 and annexin A1 levels in wheezy infants. The levels of lipoxin A4 and annexin A1 were found to be low in wheezy infants. We hope that these results will lead to novel therapeutic options for asthma in cases where an optimal treatment modality is lacking.

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Aspergillus lateral-flow device (LFD) was recently introduced as a practical tool for the diagnosis of invasive aspergillosis (IA). We investigated the performance of Aspergillus-LFD as a point-of-care test for the diagnosis of IA. Serum samples were collected twice weekly from patients who received intensive chemotherapy for acute leukemia, or recepients of allogeneic stem cell transplantation. Aspergillus galactomannan (GM) antigen,

Cisplatin is a widely used anticancer drug but, it can produce undesirable effects such as hepatotoxicity even in therapeutic doses. The underlying mechanism in hepatotoxicity has been attributed to free oxygen radicals. The present study was designed to determine the possible protective effects of grape seed extract (GSE) and Origanum onites essential oil (OOEO) on liver toxicity induced by cisplatin. Ninetysix-male Wistar albino rats were divided into eight groups, twelve in each (Control, GSE, OOEO, GSE+OOEO, Cisplatin, GSE+ Cisplatin, OOEO+ Cisplatin, GSE+OOEO+ Cisplatin) and followed up for 10 days. Cisplatin and OOEO were injected intraperitoneally. GSE was administered with gavage. The histopathological examination of liver tissues was performed by light microscope. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were determined in liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured in serum. Cisplatin-induced considerable hepatocyte damage under microscopic examination, and an increase in MDA levels as well as a decrease in the activities of antioxidant enzymes, including SOD, GSH-Px in liver tissues and an increase in serum ALT and AST (p< 0.001). The addition of GSE and/or OOEO significantly prevented microscopic tissue damage, reversed oxidative stress parameters and biochemical values compared to the cisplatin group (p< 0.001). In conclusion GSE and OOEO may be used in adjuvant therapy to prevent cisplatin-induced hepatotoxicity, but further studies using various doses, different time intervals, and a larger number of animals need to be carried out.Keywords: Cisplatin, Hepatotoxicity, Free Radicals, Grape, Thyme ÖZET Sisplatin, kanser tedavisinde yayg›n olarak kullan›lan fakat tedavi dozlar›nda dahi karaci¤er hasar› gibi istenmeyen yan etkilere sebep olabilen bir ilaçt›r. Sisplatinin karaci¤er dokusunda yapt›¤› hasar›n alt›nda yatan mekanizma büyük oranda serbest oksijen radikallerine ba¤l›d›r. Bu çal›flmada s›çanlarda sisplatin tedavisine ba¤l› oluflan karaci¤er hasar›nda üzüm çekirde¤i özütünün (ÜÇÖ) ve esansiyel kekik ya¤›n›n (EKY) muhtemel koruyucu etkilerinin araflt›r›lmas› amaçlanm›flt›r. Doksanalt› adet Wistar albino cinsi erkek s›çan; her biri oniki hayvandan oluflan sekiz gruba bölünerek (Kontrol, ÜÇÖ, EKY, ÜÇÖ+EKY, Sisplatin, ÜÇÖ+Sisplatin, EKY+Sisplatin, ÜÇÖ+EKY+Sisplatin), on gün süreyle takip edildi.

The visfatin level was higher in the active group than in post-treatment remission and the healthy control group. Sensitivity and specificity were similar to other inflammatory markers for assessing clinical activity, which did not improve clinical outcomes in patients with acute respiratory distress syndrome (ARDS). These findings did not provide a rationale for assessment of UC activation.

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The presence of DM and increased BMI negatively correlated with AVF maturation. High intensity of CD309 expression on monocytes was observed in patients with successful AVF maturation.

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